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Research Fellow

University College London - UCL Institute of Ophthalmology

Location: London
Salary: £35,328 per annum (Inclusive of London allowance)- Grade 7
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 19th July 2019
Closes: 19th August 2019
Job Ref: 1814338
 

The successful applicant will work on a project aimed at uncovering the molecular mechanisms underlying myopia development in children. Myopia has seen a dramatic rise in the last decades with now twice as many teenagers in the UK affected compared with the 1960s, and in the Far East, over 95% of young men are now shortsighted. Many develop a dangerously high degree of short-sightedness with a significant risk of sight-threatening conditions in adulthood, such as retinal detachment and glaucoma. One crucial feature in myopia is the elongation of the eyeball, as the sclera is becoming softer and stretchable, but the mechanisms involved are not known. This project will establish an in vitro model to look at the mechanical properties of human scleral fibroblasts, and determine the pathways regulating scleral remodeling.

The successful applicant will develop a 3D in vitro model to study scleral remodeling using adult and paediatric donor tissue, and will measure scleral fibroblasts biomechanical properties using force-monitoring devices. Routine biochemical and molecular biology techniques will be used to identify and validate the pathways involved.

The position is funded for a period of 10 months in the first instance.

The successful applicant will hold a PhD in the cell biology and/or biomechanics field, related training at the undergraduate level or higher in cell biology and/or bioengineering. They must also demonstrate the ability to lead a research project with significant degree of independence and commitment to high quality research. Desirable criteria include experience in 3D tissue culture and imaging.

Applicants should apply online. To access further details about the position and how to apply please click on the ‘Apply’ button above.

Informal enquiries about the post may be made to Dr Maryse Bailly (email: m.bailly@ucl.ac.uk ). If you have any enquiries regarding the application process please email: hr.ioo@ucl.ac.uk .

Closing Date: 19/8/2019

Latest time for the submission of applications: 23:59.

UCL Taking Action for Equality

We will consider applications to work on a part-time, flexible and job share basis wherever possible.

Our department holds an Athena SWAN Bronze award, in recognition of our commitment to advancing gender equality.

   
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