|Salary:||£31,302 to £33,199 per annum (Grade 7)|
|Placed On:||29th July 2019|
|Closes:||20th September 2019|
Contract Type: Fixed term until 31 December 2021
Working Pattern: 100% FTE
Faculty: Faculty of Science
A BBSRC funded Research Associate position is available in the laboratory of Professor David Strutt to investigate the molecular organisation of the Fat and Dachsous atypical cadherins at cell junctions and how this organisation contributes to the planar polarisation of epithelial tissues.
The Strutt lab is interested in understanding the molecular basis of ‘planar polarity’: the phenomenon whereby cells within a sheet interact and adopt a common orientation in the plane of the sheet. This project will investigate how the Fat and Dachsous atypical cadherins form polarised intercellular complexes at cell junctions in epithelial tissues. Bulk and single molecule (‘super-resolution’) microscopy techniques will be used to study Fat and Dachsous protein localisations, dynamics and clustering behaviours, together with structure-function analysis, in a reconstituted heterologous tissue culture system and in vivo in using Drosophila wing as a model simple epithelium. The ultimate aim will be to understand how individual molecular interactions at the nanometre scale result in tissue patterning at the millimetre scale.
Applicants must have a PhD (or be close to completion) and practical experience in cell biology and/or developmental biology as relevant to the project, good quantitative skills, and be able to demonstrate excellent research productivity. You will be expected to have excellent interpersonal and communication skills, and be able to work independently, efficiently and to a high standard.
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