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Research Fellow (Computational and Statistical Analysis of Spatial Dynamics in Human Eggs) (102007-089)

University of Warwick - Department of Mathematics

Location: Coventry
Salary: £30,942 to £40,322 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 14th August 2019
Closes: 25th September 2019
Job Ref: 1822815
 

Fixed term contract for 5 years, 36.5 hours per week. 
The post is for 60 months, start date ideally before Jan 2020. 

Applications are invited for a postdoctoral research fellow to work on the computational and statistical analysis of the spatial organisation of chromosomes in human egg development. Chromosome organisation and dynamics during egg development is a complex mechanical process that is poorly understood in humans.

You will join an interdisciplinary team joint between Warwick and Edinburgh, and undertake the analysis of the data generated on the project by developing bespoke analysis tools utilising a range of computational and statistical methodologies. This includes developing tracking software for chromosomes from 3D image sequences, statistical modelling of object shape (eg mixtures of gaussians), optimisation methods, mutli-variate analysis and experimental design techniques. The overall aim of the project is to deliver the first comprehensive analysis of chromosome separation during the first and second female divisions of the egg and early embryonic cell divisions in humans, and thus has direct relevance to understanding human infertility.

The ideal candidate will have a relevant PhD, e.g. in statistics/mathematics/physics/ computer science/data science, and have a background in computation, for instance either in developing algorithms for (statistical) image analysis or analysis of large complex data sets. A good background in statistics is desirable as the project will involve developing algorithms incorporating a range of statistical models/tests (mixture models, multiple hypothesis testing), and also involve multivariate modelling and experimental design. Candidates should be able to programme in MatLab (our current tracking software KiT is in MatLab), whilst an ability to programme in ImageJ, C++ or similar will be an advantage. A willingness and enthusiasm for communicating with biologists is encouraged. A background in biology is NOT required.

Applications via the HR website should include 1) a letter of application outlining previous research experience/significant results and why you are interested in the post, 2) a CV, 3) a list of publications, and 4) links to a small selection of reprints/preprints/publications from your PhD/latest research post as appropriate. Scientific queries about the project can be made to Prof Burroughs, N.J.Burroughs@warwick.ac.uk, or see his website https://warwick.ac.uk/fac/cross_fac/zeeman_institute/staffv2/burroughs/.

Interviews will take place in October 2019.

Full details of the duties and selection criteria for this role are found in the vacancy advert on the University of Warwick jobs page. You will be routed to this when you click on the Apply button.

   
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