|Salary:||£32,236 to £39,609|
|Placed On:||22nd August 2019|
|Closes:||19th September 2019|
Our laboratory studies the relationship between the sphingolipid disorder, Gaucher disease, and disordered immunity, inflammation and lymphoid cancer using the mouse to support clinical studies. We have shown that inducible deletion of the murine Gba1 gene in hematopoietic cells leads not only hematological and visceral manifestations of Gaucher disease but to the development of onco-inflammatory disease. There is disordered immunity with lymphoproliferation, monoclonal gammopathy and B-cell lymphoma-myeloma - a frequent cause of death in affected patients (Pavlova et al., B cell lymphoma and myeloma in murine Gaucher's disease. J Pathol.2013; 231:88-97). Opportune intervention with the potent and specific oral inhibitor of glycosphingolipid biosynthesis, eliglustat, prevented the onset of these fatal cancerous abnormalities (Pavlova EV et al., Inhibition of UDP-glucosylceramide synthase in mice prevents Gaucher disease-associated B-cell malignancy. J Pathol.2015;235:113-24). We now wish to explore these and related phenomena experimentally for their scientific and mechanistic importance as well as for potential therapeutic application.
To accelerate our understanding of the mechanistic basis of these extraordinary phenotypes, we seek an enthusiastic and creative colleague who is interested in conducting laboratory experiments using molecular cell biology, genetics and flow cytometry approaches. The programme of work will involve in vivo studies that exploit new methods for manipulating the murine genome and mechanistic hypothesis-testing. Experience in medical sciences and the study of rare diseases, molecular cell biology, as well as an interest in the contemporary pathological sciences would be a great advantage.
For informal inquiries please contact Dr Elena Pavlova (email@example.com)
Fixed-term: The funds for this post are available until 30 September 2022 in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check. This appointment also requires a Research Passport application.
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Closing date: 19th September 2019
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