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Research Associate (Fixed Term)

University of Cambridge - Department of Medicine

Location: Cambridge
Salary: £32,236 to £39,609
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 22nd August 2019
Closes: 19th September 2019
Job Ref: RC20417
 

Our laboratory studies the relationship between the sphingolipid disorder, Gaucher disease, and disordered immunity, inflammation and lymphoid cancer using the mouse to support clinical studies. We have shown that inducible deletion of the murine Gba1 gene in hematopoietic cells leads not only hematological and visceral manifestations of Gaucher disease but to the development of onco-inflammatory disease. There is disordered immunity with lymphoproliferation, monoclonal gammopathy and B-cell lymphoma-myeloma - a frequent cause of death in affected patients (Pavlova et al., B cell lymphoma and myeloma in murine Gaucher's disease. J Pathol.2013; 231:88-97). Opportune intervention with the potent and specific oral inhibitor of glycosphingolipid biosynthesis, eliglustat, prevented the onset of these fatal cancerous abnormalities (Pavlova EV et al., Inhibition of UDP-glucosylceramide synthase in mice prevents Gaucher disease-associated B-cell malignancy. J Pathol.2015;235:113-24). We now wish to explore these and related phenomena experimentally for their scientific and mechanistic importance as well as for potential therapeutic application.

To accelerate our understanding of the mechanistic basis of these extraordinary phenotypes, we seek an enthusiastic and creative colleague who is interested in conducting laboratory experiments using molecular cell biology, genetics and flow cytometry approaches. The programme of work will involve in vivo studies that exploit new methods for manipulating the murine genome and mechanistic hypothesis-testing. Experience in medical sciences and the study of rare diseases, molecular cell biology, as well as an interest in the contemporary pathological sciences would be a great advantage.

Our lab (https://www.med.cam.ac.uk/cox/) is in the Department of Medicine (https://www.citiid.cam.ac.uk/) and located on the Cambridge Biomedical Campus (https://cambridge-biomedical.com/).

For informal inquiries please contact Dr Elena Pavlova (ep316@medschl.cam.ac.uk)

Fixed-term: The funds for this post are available until 30 September 2022 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check. This appointment also requires a Research Passport application.

To apply online for this vacancy and to view further information about the role, please visit :

http://www.jobs.cam.ac.uk/job/22922.

Closing date: 19th September 2019

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference RC20417 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

   
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