|Salary:||£35,328 to £38,303 per annum|
|Placed On:||16th September 2019|
|Closes:||21st October 2019|
Specific unit / Sub department Cancer Section - Developmental Biology and Cancer Programme
(inclusive of London allowance) £35,328 - £38,303 per annum
Duties and Responsibilities
Applicants are invited for a Research Fellow within the laboratory of Dr Owen Williams at the UCL Great Ormond Street Institute of Child Health.
The overall objective of this project is to generate pre-clinical data that will validate and promote the repositioning of the anti-helminth drug mebendazole into the therapy of paediatric Acute Myeloid Leukaemia (AML). This project is based on our recent research identifying potent anti-AML activity of mebendazole, through targeting the transcription factor c-MYB for proteasomal degradation. The current project will take this research to the next stage by examining the anti-leukaemia activity of mebendazole in a number of different AML models, including patient-derived AML xenografts, and its potential synergy with existing and experimental anti-AML therapies. We envisage that this research will form the basis for initiating clinical trials with the aim of translating mebendazole into paediatric AML therapy.
The role of the post holder will be to perform molecular biological, haematopoietic and biochemical experiments using leukaemia cell lines, patient-derived xenograft leukaemia cells and pre-clinical leukaemia models.
This post is funded for 3 years in the first instance.
Experience in some or all of the following are essential: leukaemia cell culture, haematopoietic assays, patient-derived xenograft culture, lentiviral transduction, quantitative rt-PCR, routine protein biochemistry and western blot analysis, and flow cytometry. Experience in advanced cell biology and in vivo experimentation is essential. Applicants must have (or at least submitted) a PhD in experimental biology, particularly haematopoietic and leukaemia research, and have a publication record commensurate with research experience in a relevant subject area.
Applicants should apply online. To access further details about the position and how to apply please click on the ‘Apply’ button above.
If you have any queries regarding the vacancy or the application process, please contact Susan Lloyd, Programme Administrator, Email: firstname.lastname@example.org
UCL Taking Action for Equality
21 Oct 2019
Latest time for the submission of applications
Our department holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality.
This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff.
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