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Biophysics Scientist

The Beatson Institute for Cancer Research - Drug Discovery Unit

Location: Glasgow
Salary: £23,000 to £33,000 depending on experience
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 14th February 2020
Closes: 13th March 2020
Job Ref: REQ00089

3 year contract

Starting Salary £23,000 - £33,000, depending on experience

The Drug Discovery Unit at the CRUK Beatson Institute in Glasgow, is one of five Cancer Research UK funded Drug Discovery teams across the UK.  These teams aim to work closely with local cancer experts to develop new and innovative therapies that strike at the core of cancer pathology.  Using current screening and structural sciences/biophysics technologies, industry standard medicinal chemistry and complex biological modelling systems, the Drug Discovery Group at the Beatson is tackling some of the most challenging targets in cancer biology.  

We currently have an exciting opportunity as a consequence of the expansion in our drug discovery portfolio.  If you are a highly skilled, enthusiastic individual who takes an innovative and proactive approach to research challenges, then we would like to hear from you.

We are looking for a talented and motivated scientist who will join a team of biophysicists in our structural sciences team.  The successful applicant will primarily use SPR, but knowledge of other techniques such as NMR and ITC is advantageous in making full use of our state of the art biophysics capabilities.

Biophysics plays an influential role in our drug discovery projects, you will work collaboratively with all teams (biophysicists, protein scientists, crystallographers, biologists and chemists) at the Beatson. 

The role requires you to use SPR, NMR and ITC to characterise protein ligand interactions, applying these to medicinal chemistry-driven projects at all stages from fragment-based hit identification through to lead optimisation.  The quality data that you produce will be critical, helping teams form an understanding of both the mechanism of action of our molecules and the target biology.

In addition, you will contribute to the development of the biophysics discipline by identifying and driving improvements and innovations that advance drug discovery projects.

Skills & Experience: 

  • A BSc, MSc or PhD in Biophysics, Biochemistry, Chemistry or a related discipline.
  • Knowledge of SPR for measuring protein-ligand interactions is desirable.
  • Experience of additional biophysical techniques (e.g. NMR and ITC) along with a solid understanding of protein science and enzymology is also desirable.
  • Experience of working in a drug discovery environment where structural and biophysical studies are central to the progression of medicinal chemistry strategies would be an advantage.
  • Excellent communication, including experience of working as part of a multidisciplinary team.

In return, we offer an inspiring, supportive and multi-disciplinary environment in a state-of-the-art, purpose built laboratory in which to further enhance your skills and knowledge of biophysics, cancer biology and drug discovery; providing you the opportunity to make a real difference to the lives of cancer patients.

Applications must be made via our website at http://www.beatson.gla.ac.uk/careers/drug-discovery/

Informal enquiries are welcome and should be addressed to Dr Justin Bower; j.bower@beatson.gla.ac.uk

Closing date for applications is March 13th,2020.

   
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