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Postdoctoral Research Scientist

The Beatson Institute for Cancer Research - Cancer Research UK Beatson Institute

Location: Glasgow
Salary: £31,604 to £41,929 (Depending on experience) plus relocation allowance where appropriate
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 26th February 2020
Closes: 10th April 2020
Job Ref: REQ00092

Organisation and Dynamics of Anti-tumour Immune Responses

Dr Ed Roberts

Starting Salary from £31,604 to £41,929 (Depending on experience) plus relocation allowance where appropriate. Initial 3 year fixed term contract.

Would you like to develop your scientific career in a research institute that is founded on the quality of its people, acknowledged for its collaborative environment and designed to promote the development of the most outstanding and dedicated scientists?  Many early career researchers have already made that decision and at present over 100 of them are now benefiting from our excellent training programme. 

The Cancer Research UK Beatson Institute supports cutting edge research into the molecular mechanisms of cancer development and is one of the leading research institutes in Europe. The Institute provides an outstanding research environment, underpinned by state-of-the-art core services and advanced technologies, with special emphasis on imaging, metabolomics, and in vivo models.

Our innovative and ambitious research themes focus on understanding the regulation of the tumour microenvironment and cancer metabolism, in particular: 

  • Intrinsic cancer cell vulnerabilities caused by cell growth
  • Interplay between the tumour microenvironment, metastasis and recurrence
  • Biology of early disease, aimed at developing a ‘Precision Prevention’ approach

We are building a new group focussed on understanding how anti-tumour immune responses are initiated in the lymph node (LN). We are interested in how the LN microenvironment is informed by signals from the periphery and how this influences downstream T cell outcomes. T cells stimulated within the tumour draining LN differentiate in a suboptimal manner and we seek to understand why and whether this can be manipulated to improve the quality and/or quantity of anti-tumour immunity.

Combining the use of multiple reporter strains, tissue clearing and image analysis techniques the role will involve examining the dynamics and organisation of dendritic cells within the tumour and the lymph node. These will be compared to those seen during an optimal anti-viral response and then modified using a combination of inhibitors and genetic manipulation to determine the functional deficiencies leading to suboptimal anti-tumour responses. We will also utilize novel reporters of Granzyme B mediated killing to directly determine how these alterations in dendritic cell phenotype directly impact T cell mediated killing of target cells in vivo.

Applicants must have a PhD in a relevant field and be driven by scientific curiosity. Existing skills with regard to mammalian cell culture, advanced imaging and flow cytometry along with experience of immunology and in vivo cancer models will be an advantage.

To find out more about this unique opportunity to establish advanced skills and expertise in the exciting field of tumour immunology please contact Dr. Ed Roberts, email ed.roberts@glasgow.ac.uk

At the Cancer Research UK Beatson Institute, we are committed to increasing the number of female scientists at this level and strongly encourage female applicants to apply. We have recently introduced a highly attractive, innovative maternity policy, which includes providing a postdoc with support and funding so that their projects can continue during their maternity leave.

All applications must be made via our website at http://www.beatson.gla.ac.uk/careers/postdoctoral-fellows/

Closing date for applications: 10th April 2020

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