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Research Associate (Fixed Term)

University of Cambridge - Department of Clinical Neurosciences

Location: Cambridge
Salary: £32,816 to £40,322
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 1st May 2020
Closes: 31st May 2020
Job Ref: ZE23072

A postdoctoral position is available working on a collaborative project between the group of Professor Clare Bryant (Medicine) and the group of Sir David Klenerman FMedSCi FRS . This  as a part of a multidisciplinary project at the UK Dementia Research Institute, within the Department of Clinical Neurosciences , University of Cambridge. This position will be based within the Department of Clinical Neuroscience and the Department of Medicine.

Dementia is the biggest health challenge of our century. The UK Dementia Research Institute (UK DRI) is the biggest UK initiative supporting research to fill this gap. The UK DRI at The University of Cambridge is a collaborative, inter-disciplinary Centre, combining world-leading expertise unique to Cambridge from chemistry, biophysics and structural biology with internationally leading research in the cell biology of neurodegeneration. Our research focuses on the mechanistic processes involved in the earliest stages of neurodegenerative disease to identify therapeutic targets with the greatest potential to prevent dementia. These processes include the spreading of misfolded tau protein, the cold shock protein response in the repair of synapses and autophagy as a protective cellular response, all of which are relevant to several different types of dementia.

The project aims to explore the molecular mechanisms by which low concentrations of protein aggregates cause increasing inflammation in glial cells over time, via triggering of Toll-like receptors.  The applicant will produce and characterize protein aggregates for the inflammatory assays and then apply different doses of these aggregates to in vitro macrophage models. The project aims to make more sensitive macrophage models by modifying or removing endogenous genes and by enabling tagging of the Myddosome to directly visualize early signaling events using fluorescence imaging.

Applicants should have experience in toll-like receptor biology, in particular with performing experiments in different types of macrophage models.  The applicant should also be familiar with using CRISPR/Cas9 techniques to remove or modify endogenous genes within macrophage models.  Experience with aggregated protein models used in studying Alzheimer's and/or Parkinson's disease in in vitro macrophage models is desirable.

For queries relating to your application or the application process, please contact

Fixed-term: The funds for this post are available for 2 years in the first instance.

To apply online for this vacancy and to view further information about the role, please visit :

Closing Date: 31st May 2020

Interview Date: Week Commencing 15th June 2020

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference ZE23072 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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