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Postdoctoral Scientist in Targeted Therapy Against Leukaemic Stem Cells

University of Oxford - Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine

Location: Oxford
Salary: £32,817 to £40,322 p.a., Grade 7
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 22nd May 2020
Closes: 5th June 2020
Job Ref: 146391

Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, John Radcliffe Hospital, Headington, Oxford

Grade 7: £32,817 - £40,322 p.a.

An exciting opportunity has arisen for a highly motivated and ambitious Postdoctoral Scientist to join Professor Paresh Vyas at the MRC Weatherall Institute of Molecular Medicine. The postholder will be based in the Vyas laboratory and will work with Professor Vyas and other investigators in the [MRC Molecular Haematology Unit][1].

The [Vyas laboratory][2] is world-leading in the study of the biology of human stem cell biology and human acute myeloid leukaemia. The applicant will use state of the art methods in single cell biology and study the impact of novel anti-leukaemic stem cell therapies, using samples from patients treated in clinical trials of novel first-in-class therapies. A key aim will be to identify the mechanisms of disease response and resistance, which are vital to understand how to optimise development of leukaemic stem cell targeted therapies.

You will hold a PhD (or near to completion: thesis submitted) in leukaemia biology, or study of stem cell biology. You will have extensive laboratory experience in complex FACS analysis and sorting, CRISPR, cell culture, single cell biology, working with in vivo models and computational experience in analysis of transcriptomic and epigenetic datasets. A strong publication record in high-impact peer-reviewed journals (at least two second tier or one first tier first author publication(s)) is a prerequisite, as well as the ability to work independently and as part of a team. You will have excellent communication and organisational skills, with the ability to manage and independently drive, innovate and complete your own research and associated activities.

This is a fixed-term position until 3 January 2023, funded by Celgene Corporation,

Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application.

The closing date for this applications is 12.00 noon on Friday 5 June 2020.

  [1]: https://www.imm.ox.ac.uk/research/units-and-centres/mrc-molecular-haematology-unit
  [2]: https://www.imm.ox.ac.uk/research/units-and-centres/mrc-molecular-haematology-unit/research-groups/vyas-group-normal-and-malignant-haematopoiesis-lab

https://my.corehr.com/pls/uoxrecruit/erq_jobspec_version_4.jobspec?p_id=146391

Closing Date: 05-JUN-2020 12:00

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