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PhD Studentship: In Blood Pressure Profiling in Orthostatic Hypotension - Predicting Response to Treatment

Newcastle University - Faculty of Medical Sciences

Qualification Type: PhD
Location: Newcastle upon Tyne
Funding for: UK Students, EU Students
Funding amount: Not Specified
Hours: Full Time
Placed On: 22nd May 2020
Closes: 30th June 2020

Value of award

100% of UK/EU tuition fees paid and annual living expenses at UK RI rate. Successful non-EU international students will be required to make up the difference between the UK/EU fees and international fees. A research training support grant of £5000 per year is available to cover research costs and local, national and international travel (conferences and exchanges).

Number of awards: 1

Start date and duration: September 2020 for 3 years full time


Orthostatic hypotension (OH) affects 1 in 5 older people. It is a disabling condition which makes even simple everyday tasks very challenging. Despite this, the evidence base for treatment is lacking.

OH is diagnosed in the presence of a significant BP reduction on moving from a lying to a standing position. Continuous BP monitoring is becoming common place in falls, syncope and geriatrics clinics. This provides clinicians with a detailed BP profile but has little to no impact on clinical management compared to traditional BP measurement. 

It has recently been shown that the morphology of BP drop on standing upright reflects the underlying vascular pathophysiology: 1) small drop fast recovery (arteriolar); 2) medium drop slow recovery (venular); 3) large drop non recovery (mixed). There is potential for a step-change in the management of  OH using the orthostatic BP morphology to influence the choice of treatment.


Postural BP morphology will predict response to treatment in people with OH.

Ultimately the candidate will determine how we can predict who will respond to which treatments in people with OH.

Sponsor: Newcastle University (

Name of supervisor(s): James Frith and Julia Newton

Eligibility Criteria

The successful applicant will have, or expect to obtain, an upper second class or above in a biomedical or physiological area; a Masters degree (Merit or above), or additional research experience, is desirable but not essential. If your first language is not English you need an overall IELTS score of 7.0 (with at least 6.5 in all sub-skills) or equivalent language qualification. Non-UK candidates should contact regarding eligibility and fees.

How to apply

You must apply through the University’s online postgraduate application system by creating an account. To do this please select ‘How to Apply’ ( and choose the ‘Apply now’ button.

All relevant fields should be completed, but fields marked with a red asterisk must to be completed. The following information will help us to process your application. You will need to:

  • Click on programme of study
  • Insert 8300F in the programme code section and click search
  • Select Programme name ‘PhD in the Faculty of Medical Sciences (full time) – Population Health Sciences Institute’
  • Insert PH003 in the studentship/partnership reference field
  • Attach a covering letter and CV. The covering letter must state the title of the studentship, a brief proposal of your research project including likely methods to be used. Please quote reference code PH003 and state how your interests and experience relate to the project you propose
  • Attach degree transcripts* and certificates and, if English is not your first language, a copy of your English language qualification.

*You will not be able to submit your application until you have submitted your degree transcript/s.


Professor Julia Newton (

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