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Research Fellow

UCL Institute of Neurology - UK Dementia Research Institute

Location: London
Salary: £36,028 to £43,533 including London Allowance (Grade 7)
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 20th November 2020
Closes: 15th December 2020
Job Ref: 1873223

Dementia is the greatest health challenge of our century.

To date there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it.

The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap.

Research from UK DRI at UCL covers the journey from the patient to the laboratory and back to the patient with improved diagnosis, biomarkers and candidate therapies put to the test. 

The Bartels lab at the UK DRI at UCL is specialized and fills the gap for scientific research on synuclein multimers and lipidomics associated with PD in close collaboration with the National Hospital for Neurology and Neurosurgery and the Queen Square Brain Bank. The Bartels laboratory is dedicated to understanding the biochemical nature of α-synuclein in healthy and diseased patients.  Dr Tim Bartels first discovered disease resistant forms of the α-synuclein protein and their destabilization in Parkinson’s Disease. His lab is interested in identifying the different factors that destabilize α-synuclein and that lead to neurotoxicity. 

The Bartels lab at the UK DRI at UCL is seeking a Research Fellow. The research project will involve developing antibodies against specific species of α-Synuclein, a protein involved in neurodegeneration, and develop an ELISA or Quanterix detection assay to detect α-Synuclein in different human biofluids (blood, CSF) and establish a fluid biomarker for Parkinson’s Disease and Dementia with Lewy Bodies. 

The project will be conducted in collaboration with the Zetterberg lab at the UK DRI at UCL and Rimona Weil at the National Hospital for Neurology and Neurosurgery in Queen Square London.

Applicants should have a PhD, MD or equivalent experience in Biophysics, Biochemistry, Molecular Biology or related discipline. Experience of working in quantitative biological analytistics (ELISA, Quanterix) and with antibody development and verification is essential. IT proficiency at advanced user level, the ability to present complex scientific concepts, and an understanding of the mission of the UK DRI is also a requirement, as is the ability to be a creative and proactive thinker. Experience with handling human samples, with biomarker development, and of working with Biophysics/Biochemistry/Molecular Biology/Histology assays is desirable. 

This is a unique opportunity to work in a vibrant research environment and at the cutting edge of disease-related neuroscience within the UK DRI at UCL and UCL Queen Square Institute of Neurology, as well as through collaboration with external laboratories and industry. 

The post is available from December 2020 and is funded by UK DRI at UCL for 1 year in the first instance. Starting salary on UCL Grade 7 in the range £36,028 to £43,533 including London Allowance. 

Further Details

A job description and full person specification can be accessed using ref 1873223. To apply for the vacancy, please click the ‘Apply Now’ button below. For informal enquiries about the role please contact Dr Tim Bartels ( 

If you have any queries regarding the application process, please contact Samantha Robinson, HR Officer, UCL Queen Square Institute of Neurology, 23 Queen Square, London, WC1N 3BG (email:

We will consider applications to work on a part-time, flexible and job share basis wherever possible.

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