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Postdoctoral Research Scientist in Retinal Inflammation, Degeneration and Gene Therapy

University of Oxford - Clinical Neurosciences

Location: Oxford
Salary: £32,817 to £40,322 p.a. Grade 7
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 12th April 2021
Closes: 25th May 2021
Job Ref: 150384

Level 6, West Wing, John Radcliffe Hospital, Oxford

The Xue Lab led by Kanmin Xue, has an exciting opportunity for an ambitious postdoctoral research scientist, to undertake a novel line of investigation into the mechanism of retinal inflammation/degeneration, and to develop retinal gene therapy and CRISPR-Cas9 based gene editing to treat blinding retinal diseases.

The Group aims to apply the latest advances in molecular biology, immunology and neuroscience to better understand the mechanisms of neuroinflammation/neurodegeneration in the context of the retina and develop new treatments for clinical trials in patients with vision-threatening diseases (in particular, age-related macular degeneration and uveitis). We are not only passionate about the translational potential of our work to save sight, but also committed to building the skills and credentials of individual team members for their career development. The group works in close collaboration with the Clinical Ophthalmology Research Group of Professor Robert MacLaren, who is an international leader in retinal gene therapy, electronic retinal prostheses and robotic retinal surgery. The main objectives of our research programme are to investigate the mechanisms of retinal inflammation and degeneration; develop novel genetic or molecular therapies for retinal diseases and translate laboratory and pre-clinical studies into clinical trials.

The postholder will design, implement and control experiments effectively, and achieve the designated research outputs for the project, as well as undertake the generation of preclinical research data to Good Laboratory Practice (GLP)-like standards suitable for use in regulatory submissions, including the maintenance of electronic laboratory notebooks for recording experimental data. They will contribute to the maintenance of clinical and laboratory research standards within the Group, report and communicate on a regular basis with internal and external research collaborators and present data at regular laboratory meetings, together with presenting their research at journal clubs and conferences. They will also be expected to collaborate in the preparation of research papers for publication in peer-reviewed journals, work to standards of Good Clinical Practice (GCP) and Good Clinical Laboratory Practice (GCLP) for the collection, processing and storage of patient samples when required.

It is essential that the postholder has a PhD (or near completion) in biosciences with a background in molecular biology, biochemistry, immunology or gene editing. They should be able to demonstrate productivity in scientific research commensurate with a level of experience as evidenced by peer-reviewed publications (preferably as first author) in high impact journals. They should demonstrate abilities to design and conduct experiments, manage multiple tasks in a milestone-orientated research environment, and work cooperatively within a team. A strong academic record and the desire and potential for progression to scientific independence is also essential. Expertise in CRISPR-Cas, AAV vectors and single cell RNA-seq, computational and bioinformatic skills (e.g. programming in Python or R) would be desirable.

The post is full-time for a fixed-term of 24 months.

Only applications received before 12.00 midday on 25th May 2021 will be considered.
Interviews will be held as soon as possible thereafter.

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