About the team/job
An exciting opportunity has been created for a talented scientist to work on the development of new methodologies to identify relevant bioactivity data from the literature and other sources for incorporation into the world-leading ChEMBL database. This work will directly contribute to two on-going projects. The first, BioChemGraph, is supported by the BBSRC and aims to enhance data integration between the ChEMBL, PDBe and CSD databases. The second project is sponsored by Open Targets and will deliver evidence linking specific protein targets to disease phenotypes.
Both projects need to efficiently identify published bioactivity data associated with small molecules that interact with target proteins. In the case of BioChemGraph these data are for ligand-protein pairs where a structure of the protein:ligand complex has been deposited in the worldwide Protein Data Bank. In the case of Open Targets, the primary focus will be on published chemical probes which are active in a disease-relevant bioassay.
The successful candidate will be based in the Chemogenomics Team at the European Bioinformatics Institute (EMBL-EBI) and will closely with partners from both PDB-e and Open Targets teams, together with other groups and collaborators as required.
Your role will include the following:
You will possess a range of key skills including (a) an understanding of bioassays and bioactivity data and how these relate to drug discovery; (b) knowledge of chemical structures and their computer representations (e.g. SMILES, connection tables, InChI); (c) a sound understanding of proteins and protein structure; (d) good computer programming/scripting skills; (e) good familiarity with relevant literature and database sources of bioactivity and drug discovery data. We anticipate applying machine learning and text analytics methods to this problem in order to deliver an effective automated approach, so knowledge of this area would be a significant advantage. You also need to have excellent attention to detail, good communication skills and be able to interact not only with experts from your immediate area of expertise but also with scientists from other areas.
You might also have
Why join us
Do something meaningful
At EMBL-EBI you can apply your talent and passion to accelerate science and tackle some of humankind's greatest challenges. EMBL-EBI, part of the European Molecular Biology Laboratory, is a worldwide leader in the storage, analysis and dissemination of large biological datasets. We provide the global research community with access to publicly available databases and tools which are crucial for the advancement of healthcare, food security, and biodiversity.
Join a culture of innovation
We are located on the Wellcome Genome Campus, alongside other prominent research and biotech organisations, and surrounded by beautiful Cambridgeshire countryside. This is a highly collaborative and inclusive community where our employees enjoy a relaxed atmosphere. We are committed to ensuring our employees feel valued, supported and empowered to reach their professional potential.
Enjoy lots of benefits:
For more details please see our employee benefits page.
What else you need to know
|Salary:||Technical Officer (gr. 4-6)|
|Placed On:||9th June 2021|
|Closes:||6th July 2021|
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