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Research Associate in Chemical Biology (Francis Crick Institute)

Imperial College London - Department of Chemistry, Faculty of Natural Sciences

Location: London
Salary: £41,593 to £49,210 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 1st September 2021
Closes: 28th September 2021
Job Ref: NAT00991
 

Salary: £41,593 - £49,210 per annum

Location: The Francis Crick Institute

Job Summary

A postdoctoral position in chemical biology is available within the Chemistry Department at Imperial College, London, to work in the Walport laboratory (https://www.crick.ac.uk/research/labs/louise-walport) based at the Francis Crick Institute.

The Walport lab is a highly interdisciplinary lab that uses a wide variety of techniques, spanning from synthetic and peptide chemistry to cell biology, to study proteins involved in the regulation of post-translational modifications. Our location in the Francis Crick Institute affords us access to a wealth of state-of-the-art technologies and expertise through the Scientific Technology Platforms alongside the stimulating environment provided by both the Crick and the Imperial College Chemistry Department.

We are seeking a motivated and enthusiastic chemical biologist to carry out novel research employing an mRNA-display-based peptide discovery platform, the RaPID system, to discover tools to better understand protein citrullination. Your work will involve developing new selection protocols to identify chemical modulators of the peptidyl arginine deiminases; enzymes with key roles in inflammatory diseases and various cancers. The project will involve developing and optimising new peptide selection schemes to identify candidate peptides; biophysical and structural characterisation of identified peptides; lead peptide optimisation; and peptide characterisation and testing in cells. The project will be multidisciplinary, involving synthetic and peptide chemistry, biophysical characterisation of peptide hits, structural biology and cell biology. We are therefore seeking someone with experience in a selection of these techniques and a willingness to learn others as dictated by the project. Experience with the development, optimisation and testing of peptide inhibitors or other chemical probes would be desirable.

Duties and responsibilities

  • You will lead, conduct and record research at the forefront of modern chemical biology
  • You will contribute to other projects on a collaborative basis
  • You will draft and submit publications to refereed journals
  • You will co-supervise PhD, Masters and undergraduate students

Essential requirements

  • A PhD degree (or an equivalent level of professional qualifications) in a relevant field (e.g. chemistry, chemical biology, biochemistry)
  • Strong background in chemical biology
  • Extensive practical experience working on a multi-disciplinary project
  • A proven publication track record appropriate to their career path
  • Ability to work independently and within a team
  • Eagerness to learn new techniques

Further Information

The post is full-time and fixed term for 48 months and will be based at the Francis Crick Institute.

*Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant within the salary range £36,694 - £39,888 per annum

The Department of Chemistry proudly holds an Athena SWAN Gold Award and strives to provide a working environment where all our staff feel fully supported to flourish and excel. The Department of Chemistry is committed to promoting the wide range of Family Friendly policies and associated initiatives offered by the College.

To apply, candidates should complete the online application form.

Should you require and further details on the role please contact Dr Louise Walport: l.walport@imperial.ac.uk

Closing date: 28/09/2021

To apply, visit www.imperial.ac.uk/jobs and search by the job reference NAT00991.

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