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Post-doctoral Research Associate (Fixed Term)

University of Cambridge - Cambridge Institute for Medical Research (CIMR)

Location: Cambridge
Salary: £27,116 to £40,927
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 9th September 2021
Closes: 10th October 2021
Job Ref: SE28092

Applications are invited for an enthusiastic and committed post-doctoral scientist to join a vibrant team investigating the role of the microtubule severing protein spastin in genetic neurological disease.  This project is based in the group of Dr Evan Reid at Cambridge Institute for Medical Research and is funded for up to 3.5 years by the Medical Research Council.

The project aims to understand the inter-related functions of spastin and a related protein called protrudin in the pathogenesis of axonal degeneration. The work will be at the interface between cell biology (especially membrane traffic) and molecular neuroscience, and will involve exploration of the mechanistic roles of the two proteins at contact sites between the endoplasmic reticulum and other intracellular organelles.

The lab employs an integrated approach that combines state of the art cell biology, biochemistry, proteomics, functional genomics and stem cell-derived neuronal modeling. We aim to produce high quality research that stands the test of time.

Cambridge Institute for Medical Research is a centre of excellence that has a strong focus on understanding the molecular mechanisms of disease, with the aim of translating basic discoveries to clinically meaningful therapies.

Candidates must have experience in molecular cell biology or molecular neuroscience, and must by the time of appointment have a PhD in the biological, biochemical or biomedical sciences, with additional post-doctoral experience being desirable but not essential. They will have either published or have in preparation at least one first author primary peer-reviewed research article in a well-regarded journal.

A background in membrane traffic or molecular neurobiology would be very advantageous and experience in one or more of the following highly desirable; CRISPR-Cas genome editing, stem cell culture and neuronal differentiation, fixed or live cell immunofluorescence microscopy (especially super-resolution), lentiviral delivery of RNA or DNA to cultured cells.

Applicants will be expected to work closely within a highly interactive group, to have a friendly and collegiate outlook, to have good written and verbal communications skills, to be well-organised and have the ability to work calmly to meet deadlines.

Recent publications related to this project are: 

Petrova V, Pearson CS, Tribble JR, Solano AG, Reid E, Williams PE, Geller HM, Eva R, Fawcett JW (2020) Protrudin functions as a scaffold in the endoplasmic reticulum to support axon regeneration in the adult central nervous system, Nature Communications, 11(1):5614.

 Connell JW, Allison RJ, Rodger CE, Pearson G, Zlamalova E, Reid E (2020) ESCRT-III-associated proteins and spastin inhibit protrudin-dependent polarised membrane traffic. Cellular and Molecular Life Sciences, 77(13):2641-2658. PMCID: PMC7320071

Fixed-term: The funds for this post are available for 3.5 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

To apply online for this vacancy and to view further information about the role, please visit :

http://www.jobs.cam.ac.uk/job/31348.

Initial, informal enquiries about this position should be made to Dr Evan Reid, email:  ealr4@cam.ac.uk

Please quote reference SE28092 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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