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Post-doctoral Neuronal Cell Biologist: Functional CRISPRi Screening of Parkinson's Genes in Human iPSC Neurons

University of Oxford - Department of Physiology, Anatomy and Genetics

Location: Department of Physiology, Anatomy and Genetics, Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford

Salary: Grade 8: £41,526 - £49,553 p.a.

Applications are invited for a senior post-doctoral neuronal cell biologist to lead a research project at the Oxford Parkinson's Disease Centre (OPDC) to functionally identify new genes underlying Parkinson’s disease.

This is an exciting opportunity to lead work on CRISPRi functional screening in induced pluripotent stem cell (iPSC)-derived dopamine neurons. This project will undertake a functional analysis of GWAS loci to identify new genes underlying the cellular pathology of Parkinson’s, focused on the endolysosomal system to better understand the molecular mechanisms of the disease. 

Duties include leading on design and implementation of experiments; interpretation of data; design, generation and use of CRISPRi technology; high-content imaging analysis; differentiation and analysis of iPSC-derived neurons and cell lines; preparation of data for publication; contribute ideas for new research projects and develop ideas for generating research income; manage own academic research involving small-scale project management and act as a source of information to other members of the group.

You will have a strong publication record in neurodegeneration, the ability to independently manage a research program and raise research funds and excellent knowledge of cellular models of neurodegenerative disease. The ability to supervise post-doctoral scientists and students, innovate and trouble-shoot technical problems is also essential. Applicants must hold a PhD/DPhil in a relevant area of research and have considerable experience in cellular neuroscience and molecular cell biology relevant to analysis of neuronal phenotypes.

The post is available immediately until 30th June 2024. The post will be based in the Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford.

Informal enquiries may be directed Professor Richard Wade-Martins (

Closing date for applications is midday on Thursday 7th October 2021. Interviews are likely to be held on Tuesday 14th October 2021.

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.

We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion

Location: Oxford
Salary: £41,526 to £49,553 per annum, Grade 8
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 14th September 2021
Closes: 7th October 2021
Job Ref: 153224
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