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Research Associate in Epigenomics

Imperial College London - Department of Brain Sciences

Location: London
Salary: £41,593 to £49,210
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 14th September 2021
Closes: 14th October 2021
Job Ref: MED02721

Location: White City & Hammersmith Campuses

Dementia is the greatest health challenge of our century.

To date there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it.

The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap.

We are a globally leading multidisciplinary research institute of 700 staff investigating the spectrum of neurodegenerative disorders causing dementia, with laboratory-based research groups located at Imperial College London, University College London, the University of Cambridge, Cardiff University, Edinburgh University, and King’s College London.

Job Summary

Dr Raffaella Nativio is seeking a bright, talented, highly motivated, and ambitious postdoctoral scientist to lead projects investigating basic mechanisms of epigenetic regulation and their involvement in ageing and age-related neurodegeneration. 

While ageing is the top risk factor for neurodegeneration, the underlying mechanisms have remained unclear. The epigenetic state has been implicated in ageing and lifespan of lower organisms and thus may play a pivotal role in age-related neurodegeneration. We previously identified histone posttranslational modification changes associated with healthy aging or Alzheimer’s disease (Nativio et al., Nature Neuroscience, 2018; Nativio et al., Nature Genetics, 2020). Now, we aim to investigate the epigenetic pathways, that by modulating environmental, metabolic and genetic risk, predispose or protect from neurodegeneration during the course of aging.

Duties and responsibilities

  • To take initiative in the planning of research
  • Actively participate in the research programme of the Group
  • Plan and conduct own scientific work, with appropriate supervision
  • Identify and develop suitable techniques for the collection and analysis of data
  • Analyse data
  • To ensure the validity and reliability of data at all times
  • Maintain highly organised, accurate and complete records of all experimental work
  • Present findings in regular group meetings and at workshops and conferences
  • To prepare and present reports
  • Submit publications to high quality, refereed journals
  • To provide guidance to staff and students, providing supervision as required
  • Attend relevant seminars, workshops and conferences

Essential requirements

  • Hold (or be near completion of) a PhD (or equivalent) in Biological Sciences (e.g., Molecular Biology, Biochemistry) or a closely related discipline, or equivalent research or industrial experience
  • Practical experience in a broad range of genomics/epigenomics techniques including ChIP-seq, ATAC-seq, RNA-seq, CUT&RUN, CUT&Tag, chromosome conformation capture-based methods such as 3C, HiC and HiChIP

Further Information

This is a Full Time & Fixed Term post offered initially for 12 months, with potential for extension. You will be based in the new UK DRI research labs at the White City Campus, with close links to the Department of Brain Sciences labs in the Burlington Danes Building of Hammersmith Campus.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,694 - £39,888 per annum.

Should you have any queries please contact Dr Raffaella Nativio at

Closing date: 14 Oct 2021

To apply, visit and search by the job reference MED02721

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