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Postdoctoral Research Scientist (Immunology)

Babraham Institute

Location: Cambridge
Salary: £32,200 to £36,500 per annum depending on experience
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 5th October 2021
Closes: 7th November 2021

We are seeking to recruit a Postdoctoral Research Scientist to work in the laboratory of Dr. Claudia Ribeiro de Almeida.

The successful applicant will join a recently established team, investigating the molecular and cellular mechanisms underpinning the generation of a diverse repertoire of antibodies and maintenance of genome stability in B-lymphocytes.

Our current work focuses on understanding how antibody gene diversification is regulated at the RNA level, by a class of RNA remodelling enzymes known as RNA helicases. These studies stem from our discovery on the roles of RNA helicase DDX1 and G-quadruplex (G4) RNA structures in targeting the DNA mutator enzyme AID to the immunoglobulin heavy-chain locus, to initiate Class Switch Recombination (CSR) (Ribeiro de Almeida et al, Mol Cell, 2018).

The post-holder will play a key role in advancing this work in a collaborative manner, by conducting research and providing support/training to other lab members. The research work to be undertaken by the post-holder will comprise the analysis of RNA helicase function in B lymphocyte activation and antibody gene diversification processes using novel mouse models recently developed in our lab. It is essential the candidate is able to demonstrate track record and strong skills in immunology, cellular or molecular biology; previous expertise in working with mouse models is highly desirable.

The Babraham Institute is world-renowned for its research in life sciences, and the successful candidate will be joining a dynamic and supportive network of scientists within the Immunology Programme working on a variety of topics in T- and B-lymphocyte biology. The post-holder will benefit from world-class research facilities, the collegial environment of the Institute and the wider scientific research community in the Cambridge area.

This is a limited term appointment with funding from the Wellcome Trust and the Royal Society for a period of 3 years in the first instance. A full job specification and role requirements can be found attached to this vacancy.

Applicants must hold a PhD in a Biological Sciences or equivalent qualification, and have developed an excellent track record, skills and knowledge in immunology research (ideally B-lymphocyte immunology). We will consider applications from candidates that have their thesis submitted when commencing the post. Please note that you will be appointed on the starting salary of £30,000 per annum, if you have not yet been awarded your PhD.

For more information on the work of the group please visit:

https://www.babraham.ac.uk/our-research/lymphocyte/claudia-ribeiro-de-almeida

For informal enquires, or to find out specific details about the research, please e-mail Claudia.Ribeiro@babraham.ac.uk

Closing date for applications is Sunday 7th November 2021.

NO AGENCIES PLEASE

The Babraham Institute holds a silver Athena SWAN award and is committed to promoting and developing a culture of excellence, diversity and mutual respect that supports the Institute’s ambitions and attracts highly motivated and talented people. The Babraham Institute is a Disability Confident Employer and has a positive approach to employing disabled people.

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