|Salary:||£41,593 to £49,210 per annum|
|Placed On:||8th October 2021|
|Closes:||4th November 2021|
The Cancer Research UK (CRUK) Accelerator Award is a multi-institutional consortium led by Professor Paul French at Imperial College, with core partners: the Francis Crick Institute (Crick), the Institute of Cancer Research (ICR), the IRB in Barcelona and the University of Edinburgh. The Award will develop automated imaging for 3D cancer models, including patient-derived organoids (PDO), to accelerate our ability to understand and therapeutically target complexity and heterogeneity in cancer.
Your role will be to develop and apply single-objective light-sheet microscopy systems – specifically oblique plane microscopy (OPM) – to study questions in cancer biology in 3D and/or in high throughput. This will include developing, building, testing, aligning and applying state-of-the-art optical systems. It will also include developing software to control the image acquisition process, developing software to provide high-speed pre-processing of the image data and developing software for image analysis and quantification. The hardware and software that we develop will be shared openly. As a core Accelerator technologist, you will play a critical role in shaping and applying the OPM instrument and how it is designed and configured for different applications.
Initially, you will predominantly work in London at Imperial the Crick and the ICR, and later you will need to work closely with colleagues at Edinburgh and Barcelona, which will include visits to their laboratories. You will help colleagues at partner sites to use the instruments developed to implement and optimise assays of 3D cancer models. You will also help analyse the resulting 3D image data from such assays, including the development, evaluation and refinement of new image processing tools. You will provide support and training to research staff and PhD students associated with the Accelerator project and to external collaborators where approved by the Accelerator Steering Committee.
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