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Research Associate - Basic and Medical Biosciences x2

King's College London - Stem Cells & Regenerative Medicine - Faculty of Life Sciences & Medicine

Location: London
Salary: £38,826 - £39,882 per annum, (Sp. 32) including London Weighting Allowance
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 8th October 2021
Closes: 4th November 2021
Job Ref: 034106
 

Contact details: Professor Fiona Watt, Fiona.watt@kcl.ac.uk

Location:  Guy's Campus

Job description

Two Postdoctoral Research Associate positions (PDRA) are available in the Watt lab. At the Centre for Stem Cell & Regenerative Medicine at King’s College, London. One is to explore cell fate decisions in human epidermis and the other is to contribute to the development of an autologous fibroblast therapy for scarring. Both positions are for one year in the first instance. The postdoc studying cell fate decisions will have the opportunity to spend time at the EMBL in Heidelberg. The postdoc studying fibroblasts may have the opportunity to transition into a London-based startup.

Cell fate decisions

A major focus of Professor Watt’s current research is regulation of cell fate decisions in adult mammalian epidermis. A postdoctoral position is available to study the dynamics of exit from the stem cell compartment via live cell imaging of FRET sensors in vivo and in culture. The goal of the work is to integrate single cell RNA sequencing data with mechanistic experiments. The following references provide examples of the approaches used in the lab.

Zijl, S., et al (2019) Acta Biomaterialia 84:133-145. DOI:10.1016/j.actbio.2018.12.003. PMID: 30528608.
Negri, V.A., et al 2019) Scientific Reports 9:10825. doi: 10.1038/s41598-019-47232-2. PMID: 31346203.
Hiratsuka, T., et al (2020) Proc. Natl Acad. Sci. USA, Proc. Natl Acad. Sci. USA 117:17796-17807. doi: 10.1073/pnas.2006965117. PMID: 32651268.
Reynolds, G., et al (2021) Science 371(6527):eaba6500. doi: 10.1126/science.aba6500.PMID: 33479125.

Fibroblast therapies

Previous studies in mouse and human skin point to the existence of subpopulations of fibroblasts with different functions. Our concept is that certain subpopulations of fibroblasts could resolve scarring following injection into patients. A postdoctoral position is available to develop technologies and characterisation tools with a view to progressing to safety studies in humans. The following references provide some background to the project.
Driskell, R.R., et al (2013) Nature 504: 277–281. doi:10.1038/nature12783. PMID: 24336287.
Philippeos, C., et al (2018) J. Invest. Dermatol. 138:811-825. PMID: 29391249.
Rognoni, E., et al (2018) Mol. Syst. Biol. 14: e8174. DOI 10.15252/msb.20178174. PMID: 30158243.
Culley, O.J., et al (2021) Front Cell Dev Biol. 2021 Apr 6;9:628039. doi: 10.3389/fcell.2021.628039 .PMID: 33889572.

The posts will be offered on an a fixed-term contract until 30 Nov 2022 in the first instance

Full-time posts - 100% full time equivalent

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