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Senior Research Associate

University of Bristol - Faculty of Health Sciences

Location: Bristol
Salary: £38,587 to £43,434 per annum (grade J)
Hours: Full Time
Contract Type: Permanent
Placed On: 13th October 2021
Closes: 22nd November 2021
Job Ref: ACAD105635

We are seeking an experienced post-doctoral researcher to drive forward a research program examining the role of the IL-23 pathway in inflammatory eye disease, working primarily with Dr Dave Copland and Professor Andrew Dick as part of a wider collaboration.

Uveitis as the leading cause of blindness in working age adults in the developed world and is characterised by immune-mediated inflammation of the uvea. As part of the recently established ORBIT consortium, we have identified a novel T cell population resident in the anterior region of the human uvea. Analogous to IL-23R+ cells that mediate systemic inflammatory diseases (including IBD, psoriasis and Spondyloarthropathy), these are considered potential drivers for human Uveitis. Using an IL-23 driven mouse model of uveitis we have demonstrated the requirement of this novel T cell population to elicit ocular inflammation.

As the successful applicant, you will take a lead role in this project, and using a combination of vivo assessment (clinical imaging) and ex vivo cell and tissue techniques (multi-parameter flow cytometry, confocal microscopy, single cell transcriptional profiling) to characterize the spatial localization and tissue stromal interactions of these cells. This pharma-funded research programme runs in parallel with partners at the Kennedy Institute, who are undertaking similar assessment in post-mortem human uveal tissue samples. Enhanced understanding of how this population contributes to ocular inflammation will inform future therapeutic development and evaluation of novel inhibitors of the IL-23 pathway.

What will I be doing?

Over the next 36 months you will:

  • Organise, co-ordinate and perform laboratory research experiments. This will include in vivo characterization (mouse models of ocular inflammation), multi-parameter flow cytometry (analyzer and cell sorting platforms), molecular biology (next-generation sequencing and bioinformatics), and fluorescence imaging (Confocal and Lightsheet microscopy)
  • Contribute/Lead writing articles that will be published in high quality peer reviewed journals
  • Liaison with related external collaborations (academic and industrial partners)
  • Provide support to other studies and members of the research group
  • Contribute to the life of the Unit, School and University
  • Be responsible for the day-to-day management of the project You will establish a robust system for project management that addresses all aspects of the research
  • Provide regular progress reports and assist in the production of study report Keeping the project to time and budget and preparing reports based on the study’s findings

You should apply if:

  • You have an active interest in immunology and immune pathobiology
  • You are excited about undertaking research that can ultimately help patients with sight loss
  • You have a track record of excellence in research and strong project management skills
  • You have demonstrable experience in at least two of the following research areas: 1. Working independently with experimental in vivo disease models. 2. Multi-parameter flow cytometry (cell sorting and analyzer platforms). 3. Working experience of fluorescence-based microscopy, including confocal and Lightsheet platforms. 4. Molecular biology experience including the use of next-generation sequencing technology and bioinformatic analyses
  • You can build strong, effective relationships with a range of people from different sectors and levels of seniority
  • You have excellent communication skills and can clearly articulate verbally and in writing
  • You are someone who can get up to speed quickly, thrives on digesting lots of information, is mindful of competing priorities, and can drive activity forward in a sustainable manner

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