|Salary:||£38,587 to £43,434 per annum (grade J)|
|Placed On:||13th October 2021|
|Closes:||22nd November 2021|
We are seeking an experienced post-doctoral researcher to drive forward a research program examining the role of the IL-23 pathway in inflammatory eye disease, working primarily with Dr Dave Copland and Professor Andrew Dick as part of a wider collaboration.
Uveitis as the leading cause of blindness in working age adults in the developed world and is characterised by immune-mediated inflammation of the uvea. As part of the recently established ORBIT consortium, we have identified a novel T cell population resident in the anterior region of the human uvea. Analogous to IL-23R+ cells that mediate systemic inflammatory diseases (including IBD, psoriasis and Spondyloarthropathy), these are considered potential drivers for human Uveitis. Using an IL-23 driven mouse model of uveitis we have demonstrated the requirement of this novel T cell population to elicit ocular inflammation.
As the successful applicant, you will take a lead role in this project, and using a combination of vivo assessment (clinical imaging) and ex vivo cell and tissue techniques (multi-parameter flow cytometry, confocal microscopy, single cell transcriptional profiling) to characterize the spatial localization and tissue stromal interactions of these cells. This pharma-funded research programme runs in parallel with partners at the Kennedy Institute, who are undertaking similar assessment in post-mortem human uveal tissue samples. Enhanced understanding of how this population contributes to ocular inflammation will inform future therapeutic development and evaluation of novel inhibitors of the IL-23 pathway.
What will I be doing?
Over the next 36 months you will:
You should apply if:
Type / Role: