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Research Associate (Senescence in Cancer)

University of Cambridge - Department of Oncology

Location: Cambridge
Salary: £33,309 to £40,927
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 3rd November 2021
Closes: 5th December 2021
Job Ref: RD26797

We are seeking to appoint a postdoctoral researcher to better understand the role of cellular senescence in cancer and to identify and validate novel targetable biomarkers.  The postdoc will be based in the laboratory of Dr Daniel Munoz-Espin, Group Leader in the Department of Oncology at University of Cambridge and co-Director of the Thoracic Cancer Programme. This post funded by a Cancer Research UK (CRUK) Programme Foundation Award is available from 1st January 2022.

Dr Munoz-Espin's research programme aims to understand the mechanisms and processes that contribute to cancer initiation, progression and relapse, which remains a formidable challenge in oncology, and how to use this knowledge for the development of more efficient therapeutic strategies in precision medicine.  We are looking for ambitious and highly motivated researchers to explore the impact of senescence in cancer, and to identify and validate novel targetable biomarkers of cellular senescence in 2D/3D cultures and in vivo, with a particular focus on lung tumours. Candidates must have a PhD in the biological/biomedical sciences, and significant experience working in cancer biology and/or cell senescence and in animal models. Skills in managing mouse models and procedures is essential for this post. Experience in patient-derived tumour xenografts (PDTXs) and/or generation of Organoids will be evaluated very positively. International training and/or interconnections with the research industry are desirable.

The successful applicant will have active access to cellular cancer models, genetically-engineered animal models of lung cancer and inducible ablation of senescence, and also to primary cells from human tissue samples in collaboration with Royal Papworth Hospital and Cambridge University Hospitals. These studies will enable us to dissect the role of senescence in cancer and identify new therapeutic targets that will be further prioritised to develop novel pharmacologically-active drugs and delivery systems for tumour eradication. The ultimate goal is the translation of our novel tools into early-phase clinical trials, and our experimental designs are optimised to facilitate such transition.

The laboratory of Dr Munoz-Espin (https://www.munoz-espinlab.com) is part of the Early Detection Programme of the CRUK Cambridge Centre, (http://www.earlydetectioncambridge.org.uk/). Our location at Cambridge Biomedical Campus affords our members ready access to state-of-the-art research equipment, clinical facilities, and the opportunity to forge collaborations with world-class laboratory scientists and clinicians.

Informal enquiries are welcomed and should be directed to Dr Munoz-Espin at dm742@cam.ac.uk.

Fixed-term: The funds for this post are available for 3 years in the first instance, with the possibility of extension up to 5 years.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

To apply online for this vacancy and to view further information about the role, please visit :

http://www.jobs.cam.ac.uk/job/29923.

Closing Date: 5 December 2021

Interview Date: 16 December 2021

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

 

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