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Laboratory Research Scientist

The Francis Crick Institute

Location: London
Salary: £28,150 to £42,250
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 5th November 2021
Closes: 4th January 2022
Job Ref: R489
 

Location: The Francis Crick Institute, Midland Road, London

Contract: Fixed Term (30 months)

Salary:            

Laboratory Research Scientist: £28,150 - £34,500

Senior Laboratory Research Scientist: £35,500 - £42,250

Short summary

The laboratory focuses on the study of the regulation of the immune response during immune challenge and infection of the lung and gut, with a major focus on immune effector molecules called cytokines and their downstream pathways. The aim of the lab is to identify immune cells and pathways contributing to protection and pathogenesis in infectious diseases including factors: (1) determining disease outcome using M. tuberculosis infected TB resistant and susceptible mice where the blood transcriptomic RNA signature resembles human TB disease; and (2) leading to or controlling pathology in models of infection of the gut, including with T. gondii and H. hepaticus.

Project Scope

The aims of this project are to validate new targets of disease outcome, identified by RNA-sequencing or flow cytometry analyses, through advanced immunohistochemistry and immunofluorescence analyses:

Advancing our knowledge of lung and gut tissue during infection using immunohistochemistry and immunofluorescence techniques

Applying microscopy techniques for analysing and capturing data from tissue immunohistochemistry and immunofluorescence

The project will require processing of tissues from in vivo mouse models and testing of antibodies directed against target immune cell populations in fixed formalin paraffin embedded (FFPE) sections. These will include lungs from M. tuberculosis infected TB resistant and susceptible mice in close collaboration with a Senior Postdoc in the Lab and a Principal Lab Research Scientist, who will conduct all the mouse in vivo TBexperiments. The position will also support similar analysis of other infections, mainly of the gut (FFPE or frozen sections), including Helicobacter hepaticus and Toxoplasma gondii infected mice, where we wish to validate targets and pathways that control different forms of pathology. This will be in close collaboration with two Postdoctoral Fellows who will perform the in vivo experiments. Pathology will be in collaboration with Senior Lab Research Scientist who strategically organises all gene-deficient mouse colonies and additionally is an experienced molecular immunologist also expert at isolating and preparing gut tissues for histopathology analysis from infected mice.

About us

At the Crick, we’re conducting research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.

We have a wide research portfolio, bringing together people in biomedical research together clinicians, physical scientists and applied scientists from our pharmaceutical partners.

We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.

We provide an excellent learning environment with dedicated education programmes and a postdoc training programme that prepares scientists for leadership roles in science.

  • If you are interested in applying for this role, please apply via our website.
  • No closing date for this role.
  • The position is open to citizens of any country and the Crick will assist in acquiring any necessary visas or work permits, if needed
  • All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
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