|Salary:||From £43,000 with benefits, subject to skills and experience|
|Placed On:||12th November 2021|
|Closes:||11th December 2021|
Location: The Francis Crick Institute, Midland Road, London
Contract: Fixed Term (3 years), Full time
The position of Bioinformatics Officer within the Bioinformatics Core Facility will provide primarily computational and bioinformatics expertise to support high throughput post-genomic technologies (next generation sequencers), within an informed biological context, not only for research scientists within the Francis Crick Institute but also for other members of the Core group. In addition this role will provide support in bioinformatics where needed.
This position will be part of an already existing Core team of 14 providing bioinformatics expertise to the Crick scientists.
Using a variety of programming, statistical and data analysis techniques you will analyse data produced by the latest high throughput genomic technologies. Typical analysis steps will cycle through quality assessment, results generation, biological interpretation and ultimately named publication. During this process you will be expected to work closely with other members of the bioinformatics team, the Downward lab and the advanced sequencing team.
The Downward lab study the effect of oncogenic RAS signalling on the tumour microenvironment in lung cancer. With the recent clinical approval of sotorasib, the first drug targeting KRASG12C, we reached an important milestone in the treatment of this cancer. The Downward lab developed two orthotopic mouse models --immune cold and immune hot-- to test the effect KRASG12C inhibitors on the cancer cells and on the tumour immune microenvironment (TIME) in vivo. In collaboration with the pharmaceutical company BMS, they generated CITE-Seq and imaging mass cytometry (IMC) data of treated and untreated tumours. Your main project will consist of analysing the CITE-Seq data and interact with other members of the team to correlate the finding with the observations made using IMC.
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
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