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Senior/Principal Scientist

Ochre Bio Ltd

Location: Oxford
Salary: From £60,000 Depending on experience
Hours: Full Time
Contract Type: Permanent
Placed On: 18th November 2021
Closes: 12th December 2021

About Ochre Bio

Ochre Bio is a biotechnology company developing RNA medicines for chronic liver disease by using advances in ‘deep phenotyping’ and testing our therapeutics directly in human livers kept alive on machines. To learn more, please visit www.ochre-bio.com.

We are looking for a talented and highly motivated scientist to join us for this exciting journey in this fast-paced research environment to support the development of medicines for one of the most pressing healthcare challenges of our time.

About the job

Think you have the computational chops to build the world’s first in silico human liver by spatially, temporally, and single-cell sequencing human livers kept alive on machines while we study them?

Or are you a total lab legend, looking to regenerate cirrhotic human livers by reprogramming them with advanced cell-specific combination RNA therapies?

Perhaps you’re a bit of an adrenaline junkie who loves hunting for new technologies and figuring out how to quickly translate them.

Then Ochre Bio has a home for you - it’s our new xlab. A skunkworks of transdisciplinary scientists from around the world who live by Clarke’s, Murphy’s and Wheaton’s Laws. We're hiring senior and principal scientists.

Salaries are highly competitive and dependent on experience. We offer unique benefits, such as covering the costs of personal/professional development programmes that enable our team to develop their scientific and soft skills.

We're a hybrid-working team. Remote working is possible for computational scientists. Experimental scientists will be based in our Oxford lab but encouraged to take time out of the lab for research and travel (to bring in new technologies). We will also consider requests for part-time work.

Main responsibilities

  • Work on a variety of projects, focusing on:
  • new diseases
  • new therapies
  • achieving scale in liver models
  • Drive multiple projects involving human samples and human primary cells
  • Process samples for NGS experiments and feel comfortable with their analysis pipelines, in particular, bulk RNAseq, sc-RNAseq and spatial sc-RNAseq
  • Interpret data, making recommendations for next steps/future directions
  • Operate laboratory equipment used for all aspects of cell/molecular biology
  • Participate in and contribute directly to scientific discussions with other members of the research group and collaborators
  • Maintain accurate and up-to-date records in electronic lab notebook.

Essential Skills

PhD in a relevant field or equivalent experience.

Experience of Computational RNA genomics with a strong biological background.

Experience of Cell and Molecular Biology with strong data analysis competencies.

Computational skills such as R, Python, AWS cloud.

Demonstrated capacity to drive multiple and complex projects within defined timelines.

Highly organised and methodical approach to work and record keeping.

Self-motivated, capable of working both independently and collaboratively in a diverse team.

Ability to multitask and adapt to changing demands within tight deadlines.

What we can offer you

A highly competitive annual salary, starting from £60,000

35 days annual and Bank Holiday leave

A 6.5% company pension contribution

Interest-free season ticket and parking permit loan

Personal and Professional Development support

How to apply

Apply to jobs@ochre-bio.co with a ~100 word cover note appended to your CV, highlighting three things that will impress us. Please clearly state your salary expectations. Successful applicants will be asked to a virtual chat before being invited to present their scientific vision to the broader team.

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