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Research Officer

Swansea University - Swansea University Medical School

Location: Swansea
Salary: £35,326 to £40,927 per annum together with USS pension benefits, Grade 08
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 24th November 2021
Closes: 6th December 2021
Job Ref: AC04919

Contract: Fixed term for 3 years. Full-time

Location: Swansea University Medical School, Singleton Campus

Swansea University Medical School is one of the leading Medical Schools in the UK. It has a large research base including the Molecular Cardiology group, a leading international team for elucidating the molecular basis of ryanodine receptor dysfunction in arrhythmias and sudden cardiac death. The Molecular Cardiology group has thus far been awarded several £million in research funding from the British Heart Foundation.

The post holder will be part of the Molecular Cardiology group, which has extensive laboratory amenities for molecular biology, biochemistry, microbiology, and tissue culture. It also houses comprehensive confocal laser-scanning microscopy and electrophysiology suites for intracellular calcium and fluorescence imaging, and for current recording through intracellular calcium ion channels, respectively.

Applications are invited for a Research Officer to provide comprehensive scientific and technical support to a British Heart Foundation funded project titled “Characterisation of ryanodine receptor association with sorcin homologues”. This research is aimed at understanding the molecular and physiological regulation of cardiac excitation-contraction coupling. The ryanodine receptor is a large protein complex that mediates the release of stored calcium to trigger myocyte contraction. This research will characterise the modulation of the ryanodine receptor calcium release channel by sorcin and related homologues. Further, it will explore the role of this association in arrhythmogenic cardiac disease.

The post holder should be able to perform laboratory technical procedures involving molecular biology, biochemistry, cell culture and confocal microscopy. Examples include cloning and plasmid DNA preparation, co-immunoprecipitation, chemical cross-linking, cell culture and calcium imaging. The post holder should have experience in some of these techniques whereas training will be provided as required.

Essential criteria

  • A PhD Degree in Biomedical Sciences or related subject.
  • An established expertise in biochemistry and fluorescence microscopy.
  • A proven portfolio of research experience in protein-protein interaction assays including co-immunoprecipitations and chemical cross-linking, as well as intracellular calcium monitoring by confocal microscopy.

The University is committed to supporting and promoting equality and diversity in all of its practices and activities. We aim to establish an inclusive environment and welcome diverse applications from the following protected characteristics: age, disability, gender reassignment, marriage and civil partnership, pregnancy and maternity, race (including colour, nationality, ethnic and national origin), religion or belief, sex, sexual orientation.

We have an under-representation of men in the area of research and would particularly welcome applications from men for this position. We also have an under representation of individuals from Black, Asian and Minority Ethnic (BAME) backgrounds and would encourage applications from these groups. Appointments will always be made on merit.

To apply for the post please click on the above 'Apply' button.

Applicants are asked to provide a completed online application providing evidence against the essential criteria in the recruitment documentation. Applicants should also attach to the application

  • Curriculum Vitae;
  • Publication list;
  • Statement detailing your research / teaching strategy

For further information please contact Dr Spyros Zissimopoulos (Spyros.Zissimopoulos@Swansea.ac.uk).

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