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Postdoctoral Training Fellow - Immune Cell Biology

The Francis Crick Institute

Location: London
Salary: From £38,800
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 4th January 2022
Closes: 5th March 2022
Job Ref: R245
 

Applications are invited for a full-time, 4-year position on Crick terms and conditions of employment. Please note this is a rolling advert with no specific closing date, which will close once the position is filled. Applications will be considered as they arrive.

Short summary

The lab is studying signalling pathways that control the biology of B and T lymphocytes. In particular we are working on pathways that control lymphocyte activation, differentiation, survival, adhesion and migration. We use a broad range of techniques including mouse genetics, biochemistry, imaging, proteomics, transcriptomics and cellular immunology. The lab currently consists of around 13 researchers including PhD students, postdocs and laboratory research scientists. For more information see the lab website.

Project Summaries

We have previously shown that the WNK1 kinase regulates T cell migration and adhesion (Köchl et al, 2016. Nat Immunol, 17, 1075-1083). In unpublished work we have found that WNK1 also regulates T cell activation and discovered a novel and unexpected signalling pathway that regulates ion and water flux across the plasma membrane, which is essential for T cell migration and activation, thereby opening up an exciting new area of investigation. The proposed research will focus on how the WNK1 pathway and ion and water flux regulate T cell migration and activation. The work will look at the role of ion and water transporters in the regulation of these processes, and is likely to use mouse genetics, cell biology, imaging, biochemistry, microfluidics and optogenetics.

Postdoctoral Training Fellows are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research. The ability to work in a team is essential.

Informal enquiries are welcome, and should be directed to Victor Tybulewicz (Victor.T@crick.ac.uk).

About us

At the Crick, we’re conducting research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.

We have a wide research portfolio, bringing together people in biomedical research together clinicians, physical scientists and applied scientists from our pharmaceutical partners.

We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.

We provide an excellent learning environment with dedicated education programmes and a postdoc training programme that prepares scientists for leadership roles in science.

  • If you are interested in applying for this role, please apply via our website.
  • No closing date for this role.
  • The position is open to citizens of any country and the Crick will assist in acquiring any necessary visas or work permits, if needed
  • All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
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