Back to search results
Header Image

Computational Senior Staff Scientist - Medical Genetics

Wellcome Sanger Institute

Contract Length: 3 years

We are seeking a highly motivated computational staff scientist to join the Martin group at the Wellcome Sanger Institute. The group investigates the genetic basis of rare and common diseases, primarily in populations with European and South Asian ancestry. We currently have projects in the following areas:

  • The role of both rare and common variants in rare developmental disorders, using data from the Deciphering Developmental Disorders study (N=13,000 exome-sequenced patients) and the Genomics England 100,000 Genomes project (N~33,000 whole-genome sequenced rare disease patients), in collaboration with GeneDx (>60,000 exome sequenced patients) and with Matt Hurles’ group. We have a particular focus on the contribution of recessive variants across diverse populations (building on previous work), and on the interplay of rare and common variants. We are also beginning new projects investigating the genetic contribution to sex differences in autism and autistic traits, and on the impact of endogamy versus consanguinity on rare disease risk.
  • The genetics of cognitive and behavioral traits, using sequence and genotype data from UK Biobank and from two large UK birth cohorts, the Avon Longitudinal Study of Parents and Children and the Millenium Cohort Study (N~20,000), in collaboration with with Matt Hurles’ group. This work is building on recent findings about the genetic overlap between rare neurodevelopmental disorders and cognitive/mental health traits in the general population (e.g. Niemi et al., Nature, 2018Gardner et al., Nature, 2022).
  • The genetic basis of complex diseases and traits in British South Asian populations, using data from the Genes & Health project (N~50,000 British Pakistani and Bangladeshi individuals with linked electronic health records). An industry consortium has recently funded exome-sequencing of the cohort to complement the existing genotype chip data. We are investigating the contribution of rare and common variants to complex disease risk, as well as the role of autozygosity.

 As a computational senior staff scientist, you will have your own primary project(s) within these broad themes, but will also contribute to other projects in the group and supervise less experienced team members. The balance of these activities is negotiable depending on your interests and skills. Prospective candidates are welcome to contact Hilary Martin hcm@sanger.ac.uk with informal queries before deciding whether to apply.

Essential Skills

Technical Skills:

  • PhD in a relevant area (genetics, genomics, bioinformatics) 
  • Strong publishing record 
  • Experience analysing large-scale human genetic data 
  • Full working proficiency in Python or Perl, R, and Unix/Linux 
  • Knowledge of the literature on rare and/or common disease genetics 
  • Knowledge of statistical methods appropriate for large-scale genetic research 
  • Demonstrates inclusivity and respect for all 

Competencies and Behaviours:

  • Enthusiasm and commitment 
  • Attention to detail 
  • Strong problem-solving skills 
  • Ability to communicate ideas and results effectively both verbally and in writing 
  • Ability to prioritise, work independently and organise own workload
  • Ability to collaborate effectively with and independently supervise less experienced scientists

Other information

Application Process:

Please apply with your CV and a Cover Letter outlining how you meet the criteria set out above and in the job description.

Applications will be considered on an ongoing basis and the role will close when a successful appointment has been made.

Location: Cambridge, Hinxton
Salary: £46,199 to £55,341 Grade 1
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 24th May 2022
Expires: 23rd July 2022
Job Ref: 84856
 
   
We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Show all jobs for Wellcome Sanger Institute …
Advert information

Type / Role:

Subject Area(s):

Location(s):

Job tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge