Back to search results

Senior Scientist - iPSC-derived Disease Models

DefiniGEN

Location: Cambridge
Salary: Up to £45,000
Hours: Full Time
Contract Type: Permanent
Placed On: 24th May 2022
Expires: 23rd July 2022

Position Summary DefiniGEN are seeking an experienced, highly motivated individual to lead the company’s liver disease model development programme.  

About us

DefiniGEN were founded in 2013 as a spin-out from Cambridge University. We use a patented differentiation process in combination with in-house gene editing to differentiate human induced Pluripotent Stem Cells (iPSC) to hepatocytes which are then used to support our client’s work in developing next generation liver therapeutics. Typically we generate models of liver disease using our technology and screen client therapeutics for activity using our in-house phenotyping capability. As our business expands we are seeking to develop further disease models and supporting bioassays and are seeking an experienced scientist who can lead and drive this critical business function.

About you

This position will have two key functions within the business. Firstly you will lead the development of DefiniGEN’s future portfolio of hepatocyte disease models and supporting phenotypic endpoints. Secondly you will be a key knowledge resource within the organisation for scientists conducting phenotypic screening and for our sales team in client and project on-boarding meetings. Therefore, expertise in iPSC-derived disease models and their characterisation is essential for this position. 

The delivery of new disease models and the conduct of client projects will be pivotal to the success of this role. Furthermore, DefiniGEN’s core business is using cell-based bioassay to demonstrate the potency of client-supplied compounds. Typically these assays are bespoke and require significant scientific input in terms of assay design, conduct and data interpretation.  The post holder will be expected to have full scientific oversight for the design and conduct of these studies and the interpretation of the resulting data to ensure maximum value to our clients. 

Key Roles and Responsibilities

  • To direct the development of DefiniGEN’s disease model portfolio and supporting phenotypic assays.
  • To provide advice and expertise on the execution of well-controlled in vitro experiments to evaluate therapeutic compounds (at low- to high throughput scale).
  • To ensure DefiniGEN remains at the forefront of technology by the continued optimisation of differentiation protocols to generate hepatocyte-like cells from iPSCs.
  • Provide technical advice, guidance and mentoring to less experienced members of the team.
  • Act as the company expert for client-specific and internal project development troubleshooting related enquiries.
  • Represent the business in client meetings and at scientific conferences.

Requirements:

  • An advanced degree (PhD or equivalent) in biological science or related field, with substantial experience in disease modelling (E)
  • Experience in maintaining and differentiating iPSC lines into disease-relevant cell types (E)
  • Strong track record of successful cell-based assay development to support drug discovery platform and compound screening (E)
  • Familiarity with genetic disease models  (D)
  • Familiarity with gene engineering tools and technologies (CRISPR/Cas9, ZFNs, etc.) and gene delivery (AAV vectors, etc.) (D)
  • Familiarity with the use of automation for cell-based bioassays (D)
  • Ability to work both independently and collaboratively in a team-science environment (E) 

E – Essential, D - Desirable

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

Job tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
More jobs from DefiniGEN

Show all jobs for this employer …

More jobs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge