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Postdoctoral Researcher in Ubiquitylation and Cancer

University of Oxford - Department of Oncology

Location: Oxford
Salary: Grade 7: In the range £33,309 - £36,382 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 23rd June 2022
Closes: 20th July 2022
Job Ref: 158274

About the role 

We have an exciting opportunity for a Postdoctoral Researcher in Ubiquitylation and Cancer to join Dr Vincenzo D’Angiolella’s laboratory at the CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford.  The group is focused on understanding how the ubiquitin system controls cancer pathogenesis and the cellular responses to treatment with chemo- and radio-therapy. The overall aim of the research project is to identify the function of KBTBD4 and other E3 ubiquitin ligases in medulloblastoma to devise novel non-invasive pharmacological treatments. 

The research project available will involve a wide range of basic and advanced biochemical, molecular and cell biology techniques including, but not limited to, mammalian cell culture, genome editing, gene expression profiling and mass spectrometry-based proteomics. You will design and perform original research, interpreting results and presenting them to senior members of the group. You will participate in scientific discussions with other members of the research group and collaborators, and contribute ideas for future research projects. You will supervise and train junior staff in cell/molecular biology/biochemistry and will be responsible with others for the biological safety and organisation of the laboratory. 

This is a full time post available on a three-year fixed term contract in the first instance. 

About you 

You will hold (or be near to completing) a PhD/DPhil on the study of ubiquitin signalling and/or cancer biology and have publication(s) in internationally recognised journals. You will have experience in preparing figures using computer programs (such as, but not limited to, Adobe Illustrator and Photoshop) and knowledge and experience of cancer databases. You will have experience in basic molecular biology techniques and proven ability to present scientific findings at conferences and/or seminars. Relevant experience in studying ubiquitin, brain cancers and cancer stem cells using cell cultures would be advantageous. 

Application Process 

If you would like to discuss this role please contact Dr Vincenzo D’Angiolella at vincenzo.dangiolella@oncology.ox.ac.uk 

You will be required to upload a supporting statement (setting out how you meet the selection criteria), a curriculum vitae and the names and contact details of two referees as part of your online application. 

Only applications received by 12 pm BST  Wednesday 20th July 2022 will be considered. 

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