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Research Fellow on Vascular Mathematical Modelling

The University of Edinburgh - CMVM/MGPHS/USHER Institute

Location: Edinburgh
Salary: £35,333 to £42,155 UE07
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 3rd August 2022
Closes: 14th September 2022
Job Ref: 3655
 

Closing date - Wednesday 14th September 2022, 5pm.

Full time, 35 Hours per week

Fixed term, available from July 2022 for 24 months.

The Centre for Medical Informatics at the Usher Institute within The University of Edinburgh is looking for an outstanding Research Fellow.

The Opportunity:

Reporting to, and working with, Dr Miguel O. Bernabeu you will conduct research centred around one of the two following areas: a) the develop of novel approaches to phenotyping retinal blood vessels [1] in animal models of stroke and investigating associations with brain phenotypes [2] and stroke outcomes, and b) the application mathematical models of vascular remodelling previously developed by the group [3, 4] to characterise the relationship between blood flow and endothelial cell migration in the development of arteriovenous malformations [5]. This is an excellent opportunity for a motivated post-doctoral researcher to join, and become a key player in, the Leducq Foundation Transatlantic Network of Excellence “ATTRACT: arterial flow as attractor for endothelial cell migration – a new concept in vascular malformation and stroke regeneration” (https://www.mdc-berlin.de/leducq-attract). The network brings together world-leading groups on vascular biology, genetics, computational biology, and stroke from seven institutions: Max Delbrück Center for Molecular Medicine Berlin, Uppsala University, University of Lisbon, The University of Edinburgh, Duke University, Yale University, Barrow Neurological Institute. Along with Dr Bernabeu, you will be responsible for the mathematical modelling efforts in the network and will have access to unique datasets providing insight into multiple scales of regulation of vascular patterning and mispatterning. You will produce material for publication and dissemination and engage with the rest of the study network partners (including travel to network meetings, both national and international) to ensure delivery of a cutting-edge multidisciplinary programme of research. Some selected publications include: 

[1] https://doi.org/10.1101/2021.11.23.469704 
[2] https://doi.org/10.1101/2021.12.13.472377
[3] https://doi.org/10.1098/rsif.2021.0113 
[4] https://doi.org/10.1371/journal.pcbi.1007715
[5] https://doi.org/10.1161/CIRCULATIONAHA.120.053047 

Informal enquiries may be directed to Dr Miguel O. Bernabeu (Miguel.Bernabeu@ed.ac.uk)

Your skills and attributes for success: 

  • PhD (or near completion) in a relevant topic.
  • Proven track record of publishing research outputs.
  • Experience in the segmentation and quantification of vascular phenotypes in angiograms; or experience in the development of multiscale mathematical models of biological systems with a focus on biomechanics/mechanobiology.
  • Experience working with microscopy data (image processing and quantification)
  • Competence in object-oriented computer programming (the group works on Python/C++/Matlab).
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