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Higher Scientific Officer: Target Validation and DNA Damage team (Prof Andrew Tutt)

The Institute of Cancer Research

Location: London
Salary: £32,000 to £44,400 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 5th August 2022
Closes: 29th August 2022
Job Ref: ID342
Key Information

Salary: Commencement on the salary range is subject to comparable skills and experience. Future progression is based on annual performance review.

This role is eligible for ICR Sponsorship.  Support will be provided for costs associated with Visa application and health surcharge

Duration of ContractFixed Term until 31 July 2025 in the first instance

Hours per week: 35 hours per week (Full time)

Closing Date: 29th August 2022 

Job Details

Research Lead: Professor Andrew Tutt 

Summary of Role  

A main focus of this role will be to expand on work that previously identified candidate TNBC targets (Patel et. al., Nature Communications, 2018). In particular the role will investigate the potential of targeting the ubiquitin ligase DTL and to explore novel approaches to targeting the mitotic kinesin HSET. The successful candidate will carry out a variety of cell biology, cell culture and target validation assays.  The successful candidate will also contribute to other projects within the team and to the smooth running and organisation of the laboratory

Key Requirements

The successful candidate must have a BSc in molecular cell biology (or equivalent qualification). Considerable experience in cell and molecular biology, and in tissue culture is essential and experience in 3D cell culture would be an advantage.

Department/Directorate Information

The Breast Cancer Now Toby Robins Research Centre at the ICR is the first centre in the UK entirely devoted to breast cancer research. Our goal is to advance research into the causes, diagnosis and treatment of breast cancer. It is located in state-of-the-art laboratory space, with excellent core facilities and is funded through a long term renewable programme grant from Breast Cancer Now. The Centre is directed by Clinician Scientist Professor Andrew Tutt. Professor Chris Lord is Deputy Director of the Centre. Our Breast Cancer Research Centre was recently awarded the 2022 AACR Team Science award with our breast cancer clinical research partners in the ICR’s CTSU clinical trial unit and Royal Marsden Hospital.

The Target Validation and DNA Damage Response team is Andrew Tutt’s own laboratory group with the Centre and works on the discovery of novel therapies and biomarkers in BRCA1/BRCA2-associated cancers and ER/HER2-negative/basal-like breast cancers – including the identification of new drug targets and therapy combination strategies (Braso-Maristany et al Nature Med 2016, Patel et al Nature Comm 2018).

We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Stephen Pettitt via email on stephen.pettitt@icr.ac.uk 

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