Back to search results

Research Assistant

University of Plymouth - Peninsula Medical School

Location: Plymouth
Salary: £31,406 to £34,304 Grade 6 per annum
Hours: Full Time, Part Time
Contract Type: Fixed-Term/Contract
Placed On: 5th August 2022
Closes: 15th September 2022
Job Ref: A8927

We are looking to recruit a motivated and experienced in vivo Research Assistant who has experience with drug administration, for an exciting project looking to test promising therapeutics in pre-clinical neuro-oncology models. This work will be undertaken at the state-of-the-art Biological Services Unit at the University of Plymouth.

Project Description:

Neurofibromatosis type 2 (NF2) is a hereditary tumour predisposition syndrome characterized by loss of the tumour suppressor protein Merlin, leading to the development of multiple nervous system tumours: schwannomas, meningiomas and ependymomas (1). Current treatment options for these tumours are limited to surgery and radiosurgery, which are not always fully effective and at times not possible. There is, therefore, an urgent need for new effective drug treatments for NF2 related tumours (2).

We have identified new potential therapeutic targets, namely AXL and MERTK receptors. We have shown that both receptors and their ligand Gas6 are strongly overexpressed in Merlin-negative schwannomas and Merlin-negative grade I meningiomas and contribute to increased proliferation and survival of tumour cells. We have successfully inhibited in vitro proliferation and survival of patient-derived tumour cells and cell lines with an AXL inhibitor and two MERTK inhibitors. We are now preparing to test these compounds in vivo using the clinically relevant schwannoma model (3).

You will help us to generate robust data, highlighting the efficacy of these drugs in vivo by assisting with drug administration, tumour sample collection and various assays to analyse therapeutic potential.

References:  1. Gutmann, Neurology.1997 Jul;49(1):267-70.  2. Blakeley, et al., Am J Med Genet A. 2012 Jan;158A(1):24-41.3. Gehlhausen, et al., Hum Mol Genet. 2015 Jan 1;24(1):1-8.

PI: Sylwia Ammoun: sylwia.ammoun@plymouth.ac.uk

Co-PI: Oliver Hanemann: oliver.hanemann@plymouth.ac.uk  +44 1752 437418

Collaborators: David Parkinson: david.parkinson@plymouth.ac.uk  +44 1752 583203

Laraba, Liyam: liyam.laraba@plymouth.ac.uk  +44 1752 583203

Please demonstrate how you meet the essential criteria outlined in the knowledge, qualifications, training and experience elements of the job description in your supporting statement.

Closing Date: 12 Midnight, Thursday 15th September 2022

Shortlisted candidates will be invited for interview on the week commencing 26th September 2022. You will be notified whether you have been shortlisted or not.

This is a full-time position working 37 hours per week on a fixed-term basis for 1 year due to funding.

Flexible working options including job share will be considered.

We offer a competitive salary package and a generous pension and holiday scheme. We also offer a range of other benefits, including ongoing development opportunities.

The University of Plymouth is a diverse, welcoming community where everyone makes a difference and is encouraged to bring their whole selves to work. To find out more about our inclusive community, initiatives such as Athena Swan and the Race Equality Charter and our range of benefits / support mechanisms such as flexible working, staff networks and enhanced maternity, paternity and adoption leave please visit our Equality, Diversity and Inclusion webpages

We particularly welcome applicants from under-represented groups at the University of Plymouth, such as BAME/BIPOC and LGBT+.

The Faculty of Health holds a Silver Athena Swan Award and the University holds a Bronze Athena Swan Award which recognises commitment to advancing women’s careers in STEMM academia.

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

Job tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
More jobs from University of Plymouth

Show all jobs for this employer …

More jobs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge