|Location:||Newcastle upon Tyne|
|Salary:||£29,619 to £34,308 per annum|
|Placed On:||23rd September 2022|
|Closes:||9th October 2022|
We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.
You will be responsible for combining existing data sets on genomic characterisation of up to 100 cases of neuroblastoma and may include further laboratory work on telomere maintenance assays. You will perform the final analyses on the datasets including some bioinformatics analysis with appropriate support, present the results at an international meeting and prepare at least one high impact, peer reviewed manuscript for publication.
Your role will involve close collaboration with other members of the group on ongoing related projects as well as supervision of students and minor administrative tasks with regards to Health and Safety, Human tissue act and sample storage.
The overall goal of this project is to undertake a genome wide examination of neuroblastoma (NB) from 4 cohorts of patients with a rare subgroup of intermediate risk NB with a relatively unfavourable prognosis compared with other intermediate risk NB in order to further our understanding of the biology of this type of NB. This group of intermediate risk patients are > 18 months of age with localised, unresectable non-MYCN amplified neuroblastoma with unfavourable histology, so called "Group 8" within the Low and Intermediate Risk Neuroblastoma (LINES) clinical trial. By combining datasets from UK patients who were treated according to, but not on an international trial, the LINES clinical trial, and subsets of German Paediatric Oncology & Haematology (GPOH) cases and Dutch cases which fall into this category, this study will be one of the largest studies of this group of patients anywhere in the world. The project will involve combining the data already obtained from copy number analysis, sequencing (both targeted and whole exome), transcriptomic and telomere maintenance (including additional analyses to be undertaken) to clinical outcome. The results will determine if some of these patients should be reclassified as high risk in the future to achieve a better clinical outcome.
This post is full time and fixed term until 30th September 2023.
Candidates are advised that interviews for this post will take place week commencing 17th October 2022.
For informal enquiries contact: Professor Deborah Tweddle, email@example.com
Find out more about the Faculty of Medical Sciences here.
Find out more about our Research Institutes here.
As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles. These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.
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