Senior Laboratory Research Scientist - Proteomics

Short summary

We have an exciting opportunity for a talented, experienced, and motivated Senior Laboratory Research Scientist in the Proteomics Scientific Technology Platform (STP) at the Francis Crick Institute. The post holder will help us provide a world class platform to contribute towards key research in collaboration with the Crick scientific community.  This is a lab-based position, responsible for driving forward projects, from experimental design through sample preparation to data analysis.

The Proteomics STP houses a broad range of mass spectrometers including a Thermo Scientific Orbitrap Eclipse Tribrid with FAIMS and ETD, Exploris 480, Q Exactive UHMR, Bruker timsTOF Pro, Waters Select Cyclic and SYNAPT G2Si HDMS.  The role will involve setting up new experiments as projects arise using the available mass spectrometry technologies to both qualitatively and quantitatively measure proteins. The successful candidate will be able to take initiative in project design and interact closely with collaborators. It is also anticipated that the successful candidate will bring on board and apply cutting-edge proteomics methods such “Single Cell Proteomics” applying the approach to discovery and translational research at the Crick. To be considered for this role the applicant must have >3 years hands-on experience of working in a proteomics mass spectrometry laboratory.

Key Responsibilities

These include but are not limited to:

• Planning of experiments, decision making about which pipeline to take, and independently executing experiments for projects.
• Performing both standard and bespoke proteomics experiments starting with sample preparation from a variety of biological sources using common biochemical methodologies for cell lysis, SDS-PAGE, in-gel, in-solution, TCA and acetone precipitation digest protocols, TMT labelling and High pH chromatographic fractionation.
• LC-MS/MS nanoUHPLC data acquisition, evaluation, and processing of raw data.
• Communication of results to collaborators.

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 22.01.2023
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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