Clinical Research Fellow (Fixed Term)

This post represents an excellent opportunity for a medically qualified trainee with an interest in oncology, endocrinology or metabolism to join a multidisciplinary team of clinical and basic scientists investigating the drivers of cancer cachexia. The central hypothesis to this work is that cachexia is driven by the tumour itself, with molecular signals from the tumour activating and interacting with hormonal pathways that result in anorexia, systemic sickness and tissue wasting. By understanding how cancer biology and the endocrine system interact, we believe we can discover novel treatments for this devastating condition which, to date, remains without an effective treatment.

The Cambridge team is part of the CANcer Cachexia Action Network ("CANCAN") group and includes oncologists, endocrinologist and psychiatrists looking to focus their established experience in understanding disorders of body weight on the problem of weight loss in cancer.

CANCAN is a US/UK consortium funded by Cancer Grand Challenges, a major initiative co-funded for 5 years by Cancer Research UK and the National Cancer Institute in the US.

The successful candidate will play a key role in undertaking human based studies, including detailed analysis of food intake and energy expenditure in a naturalistic setting. There will be ample opportunity to be involved in molecular and immunological laboratory analysis related to this project.

The post is ideally suited to clinicians who have already some previous experience in these areas but this is not essential. The primary supervisor will be Dr Anthony Coll (Clinical Biochemistry/Wellcome-MRC Institute of Metabolic Science) working closely with Dr Claire Connell (CRUK) and Professor Paul Fletcher (Psychiatry).The work will be carried out on a number of facilities on the Cambridge Biomedical Campus.

There is scope for appropriate candidates to use this opportunity to register for a higher degree (PhD or MD) and apply for Honorary Clinical status.

The successful applicant will ideally have previous research experience.

A knowledge of Good Clinical Practice (GCP) is expected and other trial specific training will be provided. There will also be the opportunity to attend other trial design related training opportunities and to present clinical data at national and international meetings.

For further information, please contact Dr Tony Coll (apc36@cam.ac.uk) please copy to Elizabeth MacRae (Business and Operations Manager): em430@medschl.cam.ac.uk .

Fixed-term: The funds for this post are available for 60 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a standard Disclosure and Barring Service check. This appointment also requires a Research Passport application.

This is an integrated appointment between the University and Cambridge University Hospitals NHS Foundation Trust ("NHS Trust"). You will therefore also be issued with an Honorary Clinical Contract by the NHS Trust. You should be aware that if your contract with the NHS Trust is terminated your employment with the University will be terminated, and vice versa.

Please ensure that you upload a covering letter, CV and a completed Additional Information for Clinical Researchers form in the Upload section of the online application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Closing date: 6th January 2023

Date of interview: To be confirmed

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