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Research Associate in Cardiac Cellular Electrophysiology

Imperial College London

Location: London
Salary: £46,593 to £48,376 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 5th June 2024
Closes: 19th June 2024
Job Ref: MED04624
 

Location:  Hammersmith Campus (East Acton) 

Job Summary 

Why are endurance trained athletes prone to atrial fibrillation? Is electrophysiological remodelling of the pulmonary vein sleeve myocytes responsible, and can it be reversed by targeting the epigenome? 

Imperial College London is seeking a postdoctoral research associate to investigate this translational research question using large and small animal models. You will join Dr Alicia D’Souza’s laboratory and undertake independent research to discover fundamental control mechanisms by which endurance exercise modifies ion channel function and the cardiac arrhythmogenic substrate. The position is part of an ongoing British Heart Foundation Intermediate Fellowship. This project gives an excellent opportunity to lead an exciting project to completion and offers further collaborative and training opportunities with world-leading research teams in the Europe and in the USA.

This research will use a range of techniques including patch clamp electrophysiology, in vivo and ex vivo pacing protocols, multielectrode array mapping. Expertise in cardiac cellular electrophysiology is essential, alongside a PhD in a relevant field, excellent communication skills and an ability to work proactively as part of a team and in a fast-paced environment. This position is available for 18 months in the first instance (extension possible subject to funding), starting 15th of July 2024.

Relevant publications

D’Souza et al, Nature Communications (2014) https://doi.org/10.1038/ncomms4775

D’Souza et al, Circulation Research (2018) doi: 10.1161/CIRCRESAHA.117.311607

Mesirca et al, Circulation Research (2021) doi: 10.1161/CIRCRESAHA.119.316386

Tikhomirov et al, Circulation Research (2024) doi:10.1161/CIRCRESAHA. 124.324571

Duties and responsibilities

The range of duties will include:

  • Undertake single cell electrophysiological studies in a mouse model of endurance exercise
  • Contribute to the development and application of experimental protocols, data acquisition, analysis and interpretation
  • Ensure the validity and reliability of data at all times with highly accurate records
  • Assist with the writing of reports to research sponsors
  • Present findings to colleagues and assist with the publication of findings
  • Provide advice to other staff and students
  • Attend relevant training workshops and conferences as necessary

Essential requirements

  • PhD-level knowledge and experience in the field of cardiac electrophysiology
  • Strong interest in electrophysiology, ion channels, cellular excitability
  • Prior experience with in vivo studies is desirable
  • Problem-solving competence, commitment, dedicated team worker
  • Record of productivity, evidenced typically by research publications

Further Information

This is a fulltime, fixed term role based at Hammersmith Campus (East Acton).

*Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £41,694 - £44,888 per annum.

Candidates will be required to complete an application form online to be considered.

Should you require any further details on the role please contact: Alicia D’Souza – a.dsouza@imperial.ac.uk

Closing date: 19/06/2024

Apply online via the above ‘Apply’ button.

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