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Research Associate - Multi-Omics of Immune-Mediated Disease

Newcastle University

Location: Newcastle upon Tyne
Salary: £33,966 to £44,263 per annum.
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 19th June 2024
Closes: 23rd June 2024
Job Ref: 27319

We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.

The Role
This is a unique opportunity to contribute your growing expertise in the integrated analyses of single cell genomic and proteomic datasets to Newcastle-led, collaborative projects supported by the NIHR Newcastle Biomedical Research Centre (BRC) for Ageing and Multiple Long Term Conditions.

We are looking for a highly motivated and methodologically-focussed researcher with a keen appreciation of immunobiology and strong computational skills to play a key role in our translational research group. Through the study of human "models" of immune-mediated disease, our large, multi-disciplinary team seeks to unravel their pathogenesis and so inform targeted therapeutic approaches that will improve outcomes for patients in the future.

You will work collegiately to apply your informatics experience, assimilating complex datasets and deploying cutting-edge analytical methods that build new knowledge with strong translational potential.

You will benefit from the sharing of ideas across our broad, collaborative network, in turn supporting skills development amongst students and colleagues within the group and presenting your findings at national and international fora.

You will hold a PhD and demonstrate enthusiasm to develop experience in computational biology in this field. You will be an adaptive team player, ready to work collaboratively and creatively across disciplines and institutional boundaries.

This post is fixed-term for a period of 24 months in the first instance.

The project
We have derived single cell sequencing (scSeq) data from the peripheral blood and tissue of people with evolving immune-mediated disease, obtained prospectively over serial time-points alongside paired genetic, epigenetic and proteomic data.

Our carefully-curated patient cohorts include BIO-FLARE and MEDALLION – respectively of rheumatoid arthritis patients in remission who stopped treatment (of whom half subsequently experienced a flare), and of cancer patients who received immune checkpoint inhibitor (ICI) treatment (half of whom went on to develop immune-related toxicity). By studying these cohorts in parallel, new insight into shared and discriminatory mechanisms of immune-mediated pathology are anticipated. With scSeq analysis as its focus, your work may include analysis of paired flow cytometric, bulk-RNAseq, CpG methylation, spatial (tissue) and serum proteomics and spatial transcriptomics data.

For informal enquiries contact: Dr Arthur G Pratt (arthur.pratt@newcastle.ac.uk) or Professor John D Isaacs (John.Isaacs@newcastle.ac.uk).

Find out more about the Faculty of Medical Sciences here: https://www.ncl.ac.uk/medical-sciences/.

Find out more about our Research Institutes here: https://www.ncl.ac.uk/medical-sciences/research/institutes/.

As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles. These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
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