Back to search results

Research Associate in Liver Cancer Biomarkers and Target Discovery

Newcastle University

Location: Newcastle upon Tyne
Salary: £33,966 to £44,263 per annum.
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 19th June 2024
Closes: 23rd June 2024
Job Ref: 27320

We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.

The Role
We seek an enthusiastic and ambitious researcher to join our team in the Translational and Clinical Research Institute to work on a unique and exciting project.

Liver cancer incidence and mortality is rising. Current therapies include surgery, locoregional treatments and medical therapies. However, patients with liver cancer are typically elderly with comorbidities and underling chronic liver disease. Responses vary widely, impacting survival. Predictive biomarkers and novel treatment strategies are needed. Cancer Research UK has funded an observational trial called HUNTER. Clinical data and samples over multiple lines of treatment for more than 1000 patients has been collected. Multiple samples datasets have and are being generated, including genomic DNA, serum proteomics, peripheral blood mononuclear cells (PBMCs) RNAseq, as well as whole slide images (WIS), immunohistochemistry and hyperion mass spectrometry of biopsy tissues.

This role will involve maintaining and further developing the datasets, building on these as enrolment, patient follow-up and research data generation is ongoing. The postholder will be responsible for maintaining our REDCap database of patient data, as well as developing a secure research environment for data sharing and an R Shiny interactive web application to facilitate visualisation and analyses.

The Research Associate will have the opportunity to apply bioinformatic analyses to these datasets (e.g. single nucleotide polymorphisms, RNAseq, serum proteome, WSI) alongside the clinical data, primarily for the identification of biomarkers that predict response to treatment. Using these biomarkers, you will build computational models using various techniques contributing to a mechanistic framework of liver cancer development and progression – informing novel therapeutic strategies.

You will work as part of a multi-disciplinary team including clinicians, bioinformaticians, AI researchers, and basic scientists at the Paul O’Gorman Building within the Newcastle University Centre for Cancer.

You will hold a PhD in relevant area. Experience of bioinformatic analysis including coding/scripting languages such as R and R Shiny, preferably in the area of cancer research. Experience in clinical database management, including secure and safe access to patient data, as well as experience in computational modelling, is essential.

This post is a full-time position, fixed term until 31st March 2028.

Please note that if you are successful to this role, you will require an NHS Honorary Contract.

For informal enquiries contact: Helen Reeves at h.l.reeves@ncl.ac.uk.

Find out more about our research here:

Find out more about the Faculty of Medical Sciences and research institutes here: https://www.ncl.ac.uk/medical-sciences/ and Research Institutes | Faculty of Medical Sciences | Newcastle University (ncl.ac.uk).

As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles. These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

Job tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
More jobs from Newcastle University

Show all jobs for this employer …

More jobs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge