Research Associate - Study of Endothelial Biology

Contract type: Fixed term contract

Work hours: 35.0 hours per week

The role

This short 7-month role is to complete a study on the effects of lipoproteins on endothelial secretion.  Initial work has identified a secretory programme driven by elevated lipoprotein and you will work to complete the mapping of the intracellular trafficking pathways involved, building on the previous work.

What will you be doing?

You will study the trafficking of fibronectin and other proteins in endothelial cells in response to lipoprotein.  Secretion will be measured by ELISA and the pathways mapped by cell imaging using confocal microscopy.  You will be responsible for maintaining endothelial cells cultures and planning your day-to-day experimental work, for accurate data keeping and records, for analysis of your data and for preparation of text and figures for publication.

You should apply if

You have significant experience in working with endothelial cells and a track record of endothelial research.  The technique base for the project is protein biochemistry and cell biology.  Experience of mass spec proteomics is needed, and you should have previous experience of studying intracellular trafficking pathways by both biochemical and cell imaging methods.

Additional information

For informal enquiries please contact Professor Harry Mellor; h.mellor@bristol.ac.uk.

Interviews will be held on 02/09/2024.

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The University of Bristol aims to be a place where everyone feels able to be themselves and do their best in an inclusive working environment where all colleagues can thrive and reach their full potential. We want to attract, develop, and retain individuals with different experiences, backgrounds and perspectives – particularly people of colour, LGBT+ and disabled people - because diversity of people and ideas remains integral to our excellence as a global civic institution.

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