Back to search results

Research Fellow

University of Leeds - Faculty of Biological Sciences - School of Molecular & Cellular Biology

Location: Leeds
Salary: £38,205 to £45,585 per annum (Grade 7)
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 22nd August 2024
Closes: 19th September 2024
Job Ref: FBSMB1284

Location: Leeds - Main Campus

Working time: 100% - we are open to discussing flexible working arrangements

Contract type: Fixed term (3 years)

Are you an ambitious researcher looking for your next challenge? Do you have an established background in molecular virology? Do you want to further your career in one of the UKs leading research intensive Universities?

An exciting opportunity is available to join the laboratory of Dr Morgan Herod to study mechanisms of hepatitis E virus (HEV) replication, funded by the Medical Research Council. HEV is a positive-sense RNA virus that encodes a polyprotein which is required for virus replication. A common theme for positive-sense RNA viruses is that the polyprotein undergoes proteolysis to generate functional proteins (termed non-structural proteins: NSPs). This processing is performed by both virally-encoded and host cellular proteases, and is generally believed to be a key step in regulating viral replication. In contrast, we recently made the exciting discovery that the polyprotein of HEV is not processed by a viral protease, thus implicating a host protease as critical in controlling viral replication (doi.org/10.1371/journal.ppat.1011529).

This position will build on these results and focus on identifying and characterising the role of host proteases in HEV replication, and define the role for HEV NSPs in the virus lifecycle. The project will involve a range of biochemical and cell biological techniques including immunoprecipitation and proteomic analyses to functionally characterise HEV proteins and identify key virus-host protein interactions. The position provides an opportunity to conduct ground-breaking research into virus-host interactions and generate a new paradigm for RNA virus replication. The project would suit an individual who has experience in working with pathogenic viruses under high containment (BSL3), working with RNA and proven ability to generate and interpret ‘omics data. The successful applicant will join an interdisciplinary laboratory shared between multiple investigators and working on a range of viruses.

The University of Leeds and the Faculty of Biological Sciences are committed to providing equal opportunities for all and offer a range of family friendly policies. The University is a charter member of Athena SWAN (the national body that promotes gender equality in higher education), and the Faculty of Biological Sciences was awarded a Silver award in 2020.  We are proud to be an inclusive Faculty that values all staff, and are happy to consider job share applications and requests for flexible working arrangements from our employees. Our Athena SWAN webpage provides more information.  

Please note that this post may be suitable for sponsorship under the Skilled Worker visa route but first-time applicants might need to qualify for salary concessions. For more information please visit: www.gov.uk/skilled-worker-visa.

For research and academic posts, we will consider eligibility under the Global Talent visa. For more information please visit: www.gov.uk/global-talent

To explore the post further or for any queries you may have, please contact:

Dr Morgan Herod 

Email: m.r.herod@leeds.ac.uk

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

Job tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
More jobs from University of Leeds

Show all jobs for this employer …

More jobs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge