Qualification Type: | PhD |
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Location: | Guildford, Singapore - Singapore |
Funding for: | UK Students |
Funding amount: | Fully and directly funded for this project only for 3 years; home/UK fees covered, plus UKRI Standard Stipend p/a, currently at £19,237 pa for 2024-25 |
Hours: | Full Time |
Placed On: | 5th September 2024 |
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Closes: | 6th October 2024 |
Reference: | PGR-2425-004 |
Mitochondria play a central role in the maintenance of homeostasis in cardiomyocytes by regulating several key processes, (e.g. cellular energetics, metabolism, and cell death). Mitochondrial dysfunction is characterised by reduced ATP synthesis and increased ROS production that can lead to cellular and ionic malfunction of the heart, including increased risk of arrhythmic events. Mechanistically, mitochondrial dysfunction is closely related to the pathogenesis of arrhythmias through regulation of the activities of sarcolemmal and mitochondrial cation channels for Na+, Ca2+, and K+, thus leading to cardiac electrical remodelling. Despite extensive research and novel treatments, conditions associated with deranged cardiac metabolism and mitochondrial functions (e.g. heart failure), are still associated with a substantial risk of arrhythmic events. Improving our understanding of the characteristics of the arrhythmic risk is likely to identify novel and more effective therapies.
Abnormal ion channel function and subsequent ventricular dysfunction has been described in hereditary cardiac diseases, such as Long QT and Brugada syndromes. The cardiac voltage-gated Na+ channel Nav1.5/Scn5a is the major isoform expressed in the mammalian myocardium and plays a fundamental role in cardiac excitability/conduction, as it initiates the action potential.
We will use gain- and loss-of-function approaches in cardiomyocytes to determine
This is an exciting, fully-funded, collaborative project between the University of Surrey (UoS) (Dr Ioannis Smyrnias and Prof Kamalan Jeevaratnam) and the National University of Singapore (NUS; https://medicine.nus.edu.sg/trp/cardiovascular-disease/) (Dr Chester Lee Drum). The student will be registered at UoS, where they will spend a minimum of 2 years, before they visit NUS for approximately 1 year to complete the project.
It is ‘Essential’ for the successful candidate to have:
Supervisors: Dr Ioannis Smyrnias, Professor Kamalan Jeevaratnam and Dr Chester Lee Drum
Entry requirements
Open to candidates who pay UK/home rate fees. See UKCISA for further information. Starting in January 2025. Later start dates may be possible, please contact Dr Ioannis Smyrnias once the deadline passes.
You will need to meet the minimum entry requirements for our PhD programme.
Applicants should have a first-class or upper second-class honours or equivalents in Biochemistry, Biomedical Sciences, Biomedical Engineering, Biological Sciences, Physiology, or similar subjects.
Practical experience of cell biology, platelet biology or cell signalling is desirable but not essential.
How to apply
Applications should be submitted via the Veterinary Medicine and Science PhD programme page.
In place of a research proposal, you should upload a document stating the title of the project that you wish to apply for and the name of the relevant supervisor.
Funding
Fully and directly funded for this project only for 3 years. Home/UK fees covered, plus UKRI Standard Stipend per annum, currently at £19,237 for 2024-25.
Application deadline: 6 October 2024
Enquiries: Contact Dr Ioannis Smyrnias
Ref: PGR-2425-004
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