Laboratory Research Scientist - Briscoe Lab

Location: The Francis Crick Institute, Midland Road, London

Project Summary

A Laboratory Research Scientist position is available in the Briscoe lab. The lab aims to understand the molecular and cellular mechanisms that underpin development, using the vertebrate neural tube as a model system.

The lab is looking for a highly motivated, proactive and enthusiastic researcher to help build upon the single-cell transcriptomics technology implemented in Maizels et al. The aim will be to develop affordable new sequencing technologies with increased throughput and resolution, facilitating novel research that would previously not be feasible.

Firstly, this work will feed into multiple on-going projects within the lab studying the transcriptional dynamics that govern cell fate decisions. Additionally, this work will connect with the projects of multiple collaborators working across clinical, diagnostic and commercial settings, who wish to apply the technology to questions spanning cancer therapeutics, immune profiling, brain disorders and neurodegenerative diseases.

The project will involve designing and performing experiments with tissue culture cells and carefully optimising novel genomics protocols. The Laboratory Research Scientist will work in collaboration with other lab members and the ability to work in a team is essential.

Key Responsibilities

These include but not limited to:

• Working with tissue culture cells
• Designing and performing sequencing and molecular biology experiments
• Operating automation protocols with liquid handling robots
• Record keeping
• Data analysis & interpretation

Key experience and competencies

The candidate should  bring strong expertise and experimental background in at least one of the fields of molecular genetics, embryonic stem cell differentiation systems, or genomics technologies. Basic knowledge of molecular cell biology (e.g. cell culture, RT-qPCR, electrophoresis gels) is essential. Preference will be given to candidates with knowledge and experience in single-cell molecular biology methods and/or lab automation through liquid handling robotics.

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 9/10/2024
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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