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Research Fellow

UCL - Great Ormond Street Hospital for Children ICH

Location: London
Salary: £43,124 to £45,372
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 9th October 2024
Closes: 22nd October 2024
Job Ref: B02-07779

About us

Our mission is to maximise and advocate for the holistic health of all children, young people and the adults they will become, through world-class research, education and public engagement. The UCL GOS ICH, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children’s health research outside North America. The 2024-29 GOS ICH strategy focuses on its five scientific programmes. GOS ICH’s activities include active engagement with children and families, to ensure that our work is relevant and appropriate to their needs. GOS ICH generates the funding for our research by setting out our proposals in high quality applications to public, charitable and industrial funding bodies and disseminates the results of our research by publication in the medical and scientific literature, to clinicians, policy makers and the wider public. The Institute offers world-class education and training across a wide range of teachin g and life learning programmes which address the needs of students and professional groups who are interested in and undertaking work relevant to child health. GOS ICH holds an Athena SWAN Charter Gold Award.

About the role

A research fellow position is available to join Professor David Long’s kidney development and disease group. The researcher will work on a Wellcome Trust funded grant using gene therapy to improve vascularisation in animal models of polycystic kidney disease (PKD). To do this, the post-holder will (i) administer viral therapies locally to the kidney in a mouse model of PKD; (ii) assess disease progression using imaging technologies such as MRI and 3-dimensional whole-mount staining and (iii) identify molecular changes in the transcriptome following gene therapy using single-cell technologies to understand the molecular mechanisms underlying this treatment. The salary offered in this post is £43,124 - £45,372 per annum and is funded for 9 months in the first instance.

About you

The post-holder will hold a PhD or equivalent in a relevant biomedical subject. Experience of undertaking research in a biomedical setting, carrying out literature searches, critical appraisal of research papers, molecular/cellular research skills (tissue culture, FACS analysis, histology) is essential. Holding a UK Home Office personal licence and experience of performing animal studies is essential. Experience in either gene therapy, vascular, renal, or developmental biology would be desirable.

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