Dr Anne Bertolotti’s pioneering research programme focuses on innovative approaches to boost stress signaling pathways to increase cellular resilience and protect from diverse diseases including neurodegenerative diseases. We have developed approaches to inhibit or activate phosphatases or kinases of the integrated stress response and are progressing towards a structural understanding of these important enzymes (Tsaytler et al., 2011, Science, 332, 91-4; Das et al., 2015, Science, 348, 239-242; Carrara, M., Sigurdardottir, A., & Bertolotti, A. 2017, Nat Struct Mol Biol; Krzyzosiak, A., Sigurdardottir, A. et al., A. 2018, Cell; Szaruga M, et al,. Nat Commun, 2023. 8;14(1):5535; Fatalska A., Hodgson G, et al., Mol Cell. 2024).
The position is for two Postdoctoral Scientists with expertise in cryoEM and/or protein biochemistry. You will be responsible for expressing, purifying phosphatases and solving their structures using a combination of approaches with the support of LMB facilities. You will have a PhD in biochemistry or structural biology or due to complete doctoral studies within 6 months of applying. Relevant experience is required, and this must be best attested by at least one impactful and original publication.
Further information about the position may be obtained from Dr Anne Bertolotti via email: aberto@mrc-lmb.cam.ac.uk
This is a three-year training and development position suitable for you if you have recently completed your doctoral studies, or you are looking to move into a new research discipline and/or need to further develop your research skills. Working with our world class scientists you will be working in an Institute renowned for its excellent scientific facilities and high-quality research.
The LMB has an inclusive and collaborative working culture, and you will be based in our state-of-the-art building on the Cambridge Biomedical Campus. We have on-site parking, cycle enclosures and excellent public transport links to the site. You will be able to access our range of excellent benefits including a staff restaurant with roof terrace, on-site nursery, sports and social facilities. You will be eligible to join our defined benefit pension scheme with an employer contribution of 16%, holiday entitlement of 40.5 days per annum (including bank holidays and privilege days) and a generous employee discount scheme. We are also committed to providing training and development opportunities including support towards role-related qualifications.
The LMB is a world-class research institute within UK Research and Innovation (UKRI). UKRI is nine research councils, working together across all disciplines and sectors. More information can be found at www.ukri.org and www.mrc-lmb.cam.ac.uk.
This role qualifies for endorsement by UKRI for a UK Global Talent Visa, for which the successful applicant is likely to be eligible to apply. Immigration costs (visa and health surcharge) can be reclaimed from UKRI after taking up the post (terms and conditions apply).
To apply and access full details of the vacancy please visit our job board via the ‘Apply’ button above.
If you are unable to apply online, please contact us at recruit@mrc-lmb.cam.ac.uk.
We actively support equality, diversity and inclusion in all our activities, processes and culture.
We are a disability inclusive employer and encourage disabled people to apply for this role. You are very welcome to contact us for information about the application process and any adjustments you may require; recruit@mrc-lmb.cam.ac.uk.
Location: | Cambridge |
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Salary: | £39,375 per annum pro rata |
Hours: | Full Time |
Contract Type: | Fixed-Term/Contract |
Placed On: | 17th October 2024 |
Closes: | 13th November 2024 |
Job Ref: | LMB 2502 |
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