Research Associate In Translational Virology

The role

We seek an enthusiastic and creative Postdoctoral Research Associate who will add their expertise to a team investigating the cellular persistence of the human retroviruses HIV-1 and HTLV-1 and novel therapeutic approaches to eliminate their viral sanctuaries. The work of the selected candidate will be aimed at elucidating the role of cellular metabolism in shaping HIV-1 replication and latency using primary cell models, as well as strategies to exploit metabolic imbalances to selectively target infected cells.

What will you be doing?

The candidate will design and perform experiments in virology and molecular biology, as well as analyse data and help in the draft of grant applications and scientific papers. Specifically, you will work to set up primary cell models of latent and productive infection using wild-type and engineered HIV-1. These models will be used to sort pure populations of infected cells and identify, through both omics analysis and targeted virological, biochemical, and molecular assays, potential metabolic hallmarks of infected cells and their “druggability”. The pharmacologic candidates identified will be then tested on primary cells of people living with HIV to assess their potential in inducing selective elimination of cells harbouring HIV-1 DNA. 

You should apply if

• You have a PhD (awarded or imminent) in Microbiology and Immunology, Virology, or related disciplines can apply.
• Previous experience working with primary blood cells and/or with models of viral infection at containment level 3 is desirable.
• You should have a proven track record for conducting and disseminating research, evidenced by publications or presentations in respected journals and conferences, respectively.

Additional information

For informal enquiries please contact Dr Iart Luca Shytaj via email: luca.shytaj@bristol.ac.uk.

Potential interview date is Wednesday 8th of May 2024

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