Postdoctoral Research Associate

University of Edinburgh - Centre for Synthetic and Systems Biology

College of Science and Engineering

Institute of Cell Biology

Bacteria, like all other cells, stay alive by maintaining adequate supplies of free energy. Under various external stresses, bacteria attempt to stay viable by distributing the available energy to processes essential for coping with the challenge, while simultaneously maintaining core cellular functions. Supported by the Human Frontiers Science Program this postdoctoral project will investigate bacterial strategies for free energy coordination by directly measuring the free energy dynamics under stress conditions.

The successful applicant will use biophysical assays for single cell measurements of the two main sources of free energy: the proton motive force (PMF) and the internal ATP levels to simultaneously monitor changes in PMF and ATP while exposing the cells to various stresses. Based on this data set, the applicant will build a mathematical model that will allow us to identify different strategies to sustain free energy.

The objective of the project is to uncover the fundamental principles behind the preservation of free energy and to offer an operational definition of ‘dead’ and ‘alive’ grounded in the biophysics of free energy flows.

The post holder will work with Dr. Teuta Pilizota at the Centre for Synthetic and Systems Biology (SynthSys), University of Edinburgh for the duration of the project (2 years), and in collaboration with Dr. Bai Fan and Dr. Chien Jung Lo, at Perking University in China and National Central University in Taiwan, respectively.

Applicants holding a PhD (or soon to be obtained) in (biological) physics, applied mathematics and systems biology are encouraged to apply. Expertise in customized microscopy, microfluidics and bacterial energetics is welcomed.

The post is fixed term for 2 years.

Closing Date: 01-NOV-2016  at 5pm GMT

For further particulars and to apply for this post please click on the 'apply' button below

The University of Edinburgh is a charitable body, registered in Scotland, with registration number SC005336.

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