Fully Funded PhD Studentship: Inhibiting IL-17 Production by Blocking Endogenous RORyt Agonists for the Treatment of Autoimmune Diseases

Swansea University - Biomedical Science

We are looking for an ambitious candidate to take on a PhD project entitled “Inhibiting IL-17 production by blocking endogenous RORγt agonists for the treatment of autoimmune diseases”. This is a collaborative project between the Oxysterol Group, the Molecular Modelling Group and Immunology Group at Swansea University Medical School. The studentship is funded by the Life Sciences Research Network Wales (www.lsrnw.ac.uk) and Swansea University for 3 years, starting in January 2017. The supervisory team are passionate in their ambition to train the next generation of biomedical scientists in drug discovery.

Interleukin-17 (IL-17) is a pro-inflammatory signalling protein which plays a pivotal role in driving autoimmunity and inflammatory diseases. Thymus retinoic acid-related orphan receptor gamma (RORγt), a nuclear hormone receptor which controls both IL-17 production by Th17 cells and conversion of naïve CD4+ T cells into Th17 cells, has emerged as a “hot” drug target for IL-17 inhibitors. A number of cholesterol related molecules, including precursors in the cholesterol biosynthetic pathway and also cholesterol metabolites are reported to activate RORγt. However, there is still debate on exactly which molecule(s) functions as the endogenous ligand driving IL-17 production in Th17 cells. The aim of this project is to elucidate the cholesterol metabolism pathway in Th17 cells and design new drugs to target this pathway.

You will work at the Institute of Life Science at Swansea University Medical School and will be trained in cutting edge technologies such as mass spectrometry, flow cytometry and in silico molecular modelling. There are also opportunities for you to present your work at national and international meetings. Students trained in our group often deliver first author publications in international journals and secure employments in biotech companies or academia. For further information, please contact Dr Yuqin Wangy. wang@swansea.ac.uk. Group website: www.griffiths-wang-lab.co.uk

Academic Requirements:

Applicants should have a minimum of a 2.1 undergraduate degree and/or a master's degree (or equivalent qualification), in biomedical science or biochemistry.

Residency Criteria:

Due to funding restrictions, this studentship is open to UK/EU students only.

Funding Details

The studentship covers the full cost of UK/EU tuition fees, plus a tax free stipend of £14,296 p.a.

Share this PhD
  Share by Email   Print this job   More sharing options
We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role: