Postdoctoral Research Assistant

University of Dundee - School of Medicine - Division of Cancer Research,Jacqui Wood Cancer Centre

Summary of Job Purpose and Principal Duties

Control of cell death during mitosis and in response to chemotherapeutic drugs

Grade 7 (£31,076 - £38,183 per annum, dependent on experience).

Applications are invited for a postdoctoral research position in the laboratory of Professor Paul Clarke to study the molecular and cellular responses to disruption of mitosis.

Anti-cancer drugs such as the microtubule poison paclitaxel target the mitotic spindle and inhibit cell division. Such drugs are often effective in the treatment of ovarian and other cancers, but there is a significant problem with resistance and severe side effects. In order to understand how the disruption of mitosis affects cancer cells and how we might exploit mitotic stress responses to improve the effectiveness of anti-cancer drugs, we need to identify the molecular mechanisms that control mitotic cell death.

Our approach to study this problem involves the analysis of key proteins in cultured cancer cell lines synchronised in the period of mitotic arrest. We will test the roles of regulators by gene editing and we will investigate their functions and regulation during mitosis. We will use live-cell imaging of fluorescent protein fusions to analyse the kinetics of protein degradation and its regulation in response to mitotic disruption and manipulation of tumour suppressors and oncogene products. We will couple these experiments on model cell lines with analysis of ovarian cancer patient derived cells to identify molecular responses to chemotherapy. This work is anticipated to find determinants of clinical responses to cancer chemotherapy and identify new drug targets with the ultimate aim of improving the outcome for patients.

We are looking for an ambitious and highly motivated Postdoctoral Researcher to join our team, which is supported by Cancer Research UK. Prior experience of relevant cell biology techniques, including microscopy and single cell assays, would be advantageous. Experience of working within the fields of mitosis or cell death (apoptosis) is desirable.

The University of Dundee is a leading institution for biomedical research and offers a vibrant research environment with world-leading facilities. Research in the School of Medicine is focused on understanding and combating disease and was given the top rating for its clinical impact at REF2014.

This position is available for 8 Months in the first instance and may become available for a longer period subject to renewal of funding.

For informal enquiries, please contact Professor Paul Clarke on 01382 383247 or

The University of Dundee is committed to equal opportunities and welcomes applications from all sections of the community.

The University of Dundee is a Scottish Registered Charity, No. SC015096

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