Research Associate


Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating, mid-life, neurodegenerative disorders for which no cure is currently available.  Large expansions of a hexanucleotide GGGGCC-repeat in the first intron of the C9orf72 gene are the most common genetic cause of both ALS and FTD. We have provided evidence supporting a role for two specific dipeptide repeat proteins, poly(GR) and poly(PR), through investigating cellular and Drosophila models (Mizielinska et al Science 2014, 345:1192-1194).

This post-doctoral position will build on this work by utilising C9orf72 patient iPSC-neurons to investigate the underlying disease mechanism, with a particular focus on transcription and translation changes using state-of-the-art ribosomal profiling.  The post holder will work as part of a collaborative team of investigators in an excellent and supportive scientific environment.

Applicants must have, or be about to obtain, a PhD in an appropriate subject (ie, cell biology/molecular biology/biochemistry/neuroscience or similar), and experience of stem cell culture and differentiation, microscopy and imaging, and molecular biology. The ability to problem-solve, manage time to meet deadlines, and communicate effectively within the team and with collaborators, is also required.    Appointment at Grade 7 will be dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Research Assistant Grade 6B (salary £29,809 - £31,432 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis (including corrections).

The post is available from November 2016, and is funded for two and a half years in the first instance by Alzheimer’s Research UK.  Starting salary on UCL Grade 7 in the range £34,056 - £34,984 per annum inclusive, superannuable.   

You should apply for this post through UCL's online recruitment – where you can download a job description and person specification using ref:  1583229.   If you have any queries regarding the application process, please contact Miss E Bertram, Personnel Manager, Institute of Neurology (email:; informal enquiries regarding the post welcome to Dr Adrian Isaacs (

Closing date for applications:   26 October 2016

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